MEDICAL TECHNOLOGY. PREVENTION AND REHABILITATION OF POST-INFECTIOUS SYNDROME (INTERNATIONAL STATISTICAL CLASSIFICATION OF DISEASES: B90-B94)



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Abstract

Post-infectious syndrome serves as a clear model of how an acute immune disorder (fighting infection) transforms into a chronic pathological condition. This, in turn, creates a stable platform for the development of long-term multisystem disorders involving various organs and tissues.

Modern advances in immunology, molecular biology, and related disciplines, as well as the emergence of new immunotropic drugs, have created the conditions for providing effective and long-term care to patients with immune disorders not only in the acute phase but also during the rehabilitation phase. These circumstances served as the basis for the development of the presented medical technology.

The aim of this work is to systematize data on pathogenetic mechanisms, develop a classification and describe medical technology for the prevention and rehabilitation of patients with post-infectious syndrome.

Materials and Methods. This study analyzed current literature and ICD-10 provisions to conceptualize the concept of "PIS." A wide range of pathogens  and affected systems (nervous, cardiovascular, gastrointestinal, musculoskeletal) are considered.

Results and Discussion. The paper provides a detailed examination of immune dysregulation as a key link in the pathogenesis of post-infectious syndromes. It describes the role of antigen persistence, autoimmune reactions, and chronic inflammation, which play an important role even in the absence of an active pathogen. Approaches to topical diagnostics of lesions of various organs and systems are also presented, as well as a list of laboratory markers necessary for the verification of immune disorders and chronic systemic inflammation. A classification of conditions united by the term "post-infectious syndrome" is proposed, based on the ICD-10 rubrication (B90–B94, G93.3, I41, U09, etc.), which allows for the unification of diagnostic approaches. A patient management strategy is described, focused on the transition from antimicrobial therapy to active screening and targeted immune rehabilitation. Methods for correcting chronic systemic inflammation and preventing the development of irreversible complications (fibrosis, organ dysfunction) are considered.

Conclusion. Prevention and correction of post-infectious syndromes is a strategic objective of modern healthcare. The developed medical technology, based on the principles of personalized medicine and aimed at long-term patient health, aligns with the priorities of scientific and technological development and forms a new model for providing medical care after infections. The proposed medical technology is a new systematized direction in the diagnosis, prevention and rehabilitation of patients with post-infectious syndrome.

About the authors

Vytaly V. Zverev

Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera

Email: vitalyzverev@outlook.com
ORCID iD: 0000-0002-0017-1892
SPIN-code: 2122-1808

PhD, MD (Biology), Full Member, Russian Academy of Sciences, Scientific Advisor, Professor, Head. Department of Microbiology, Virology and Immunology

Russian Federation, 5a Maly Kazenny Lane, Moscow, 105064; Moscow

O. A. Svitich

Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera

Email: medikas97@mail.ru
ORCID iD: 0000-0003-1757-8389
SPIN-code: 8802-5569

PhD, MD (Medicine), Professor, Full Member, Russian Academy of Sciences, Head, Laboratory of Molecular Immunology, Director, Professor, Department of Microbiology, Virology, and Immunology named after аcademician A.A. Vorobyov

Russian Federation, 5a Maly Kazenny Lane, Moscow, 105064; Moscow

Andrei A. Savchenko

Federal State Budgetary Scientific Institution "Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" Separate Subdivision "Research Institute for Medical Problems of the North";
Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation

Email: aasavchenko@yandex.ru
ORCID iD: 0000-0001-5829-672X
SPIN-code: 3132-8260

PhD, MD (Medicine), Professor, Head, Laboratory of Cellular Molecular Physiology and Pathology

Russian Federation, 660022, Russia, Krasnoyarsk region, Krasnoyarsk, Partizana Zheleznjaka str., 3G.

Edward V. Kasparov

Federal State Budgetary Scientific Institution "Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" Separate Subdivision "Research Institute for Medical Problems of the North"

Email: rsimpn@scn.ru
ORCID iD: 0000-0002-5988-1688
SPIN-code: 8848-3659

PhD, MD (Medicine), Professor, Director, Research Institute of Medical Problems of the North, Federal Research Center, Siberian Branch, Russian Academy of Sciences

Russian Federation, 660022, Russia, Krasnoyarsk region, Krasnoyarsk, Partizana Zheleznjaka str., 3G.

E. P. Tikhonova

Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation

Email: 2410454@mail.ru
ORCID iD: 0000-0001-6466-9609
SPIN-code: 8376-7373

PhD, MD (Medicine), Professor, Head, Department of Infectious Diseases and Epidemiology with a Course of Postgraduate Education

Russian Federation, 660022, Russia, Krasnoyarsk Territory, Krasnoyarsk, Partizana Zheleznyaka St., 1

Elena Anisimova

Federal State Budgetary Scientific Institution "Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" Separate Subdivision "Research Institute for Medical Problems of the North"

Email: foi-543@mail.ru
ORCID iD: 0000-0002-6120-159X
SPIN-code: 4610-7610

PhD, senior researcher of the cellular-molecular physiology and pathology laboratory 

Russian Federation, 660022, Russia, Krasnoyarsk region, Krasnoyarsk, Partizana Zheleznjaka str., 3G.

D. V. Cherdantsev

Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation

Email: rector@krasgmu.ru
ORCID iD: 0000-0002-4743-4565
SPIN-code: 6760-3354

Doctor of Medical Sciences, Professor, Acting Rector of the Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky

Russian Federation, 660022, Russia, Krasnoyarsk Territory, Krasnoyarsk, Partizana Zheleznyaka St., 1

D. J. Zdzitovecki

Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation

Email: zdz64@mail.ru
ORCID iD: 0000-0002-2498-3844
SPIN-code: 2706-0079

MD (Medicine), head of the Department and Clinic of Surgical Diseases named after prof. Yu. M. Lubensky

Krasnoyarsk

Russian Federation, 660022, Russia, Krasnoyarsk Territory, Krasnoyarsk, Partizana Zheleznyaka St., 1

A. V. Zurochka

Federal Budgetary Scientific Institution Federal Research Institute of Viral Infections "Virom" of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing;
Federal State Budgetary Scientific Institution Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: safronovaeleonora68@gmail.com
ORCID iD: 0000-0003-4371-4161
SPIN-code: 2153-3550

PhD, MD (Medicine), Professor, Honored Worker of Science of the Russian Federation, Leading Researcher, Laboratory of Immunopathophysiology; Leading Researcher, Laboratory of Transmissible Viral Diseases

Russian Federation, 620049, Ekaterinburg, st. Pervomayskaya, 106

Liana Valentinovna Ryabova

Federal State Budgetary Scientific Institution Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: lianarabowa@rambler.ru

doctor of medicine, Associate Professor, chief freelance specialist

Russian Federation

Alexey Viktorovich Novik

Federal State Budgetary Institution "National Medical Research Center of Oncology named after N.N. Petrov" of the Ministry of Health of the Russian Federation, St. Petersburg, Russia

Email: alexey.viktorovich.novik@gmail.com

doctor of medicine, senior researcher

Russian Federation

Roman Nikolaevich Borisov

Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation

Email: boron-5@yandex.ru

PhD, Associate Professor, Associate Professor of the Department

Russian Federation

Alexander Vladimirovich Semenov

Federal Budgetary Scientific Institution Federal Research Institute of Viral Infections "Virom" of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: semenov_av@niivirom.ru

doctor of biological sciences, director of the institute

Russian Federation

Vladimir Aleksandrovich Zurochka

Federal Budgetary Scientific Institution Federal Research Institute of Viral Infections "Virom" of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing;
Federal State Budgetary Scientific Institution Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: v_zurochka@mail.ru

doctor of medicine, senior researcher

Russian Federation

Maria Alexandrovna Dobrynina

Federal Budgetary Scientific Institution Federal Research Institute of Viral Infections "Virom" of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing;
Federal State Budgetary Scientific Institution Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: mzurochka@mail.ru

PhD, researcher

Russian Federation

Sergey Gennadievich Borisov

Krasnoyarsk State Budgetary Healthcare Institution Krasnoyarsk Interdistrict Clinical Hospital No. 20 named after I.S. Berzona, Krasnoyarsk, Russia

Email: borisov1207@mail.ru

surgeon, deputy chief physician for surgery

Russian Federation

Anna Aleksandrovna Anisimova

Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation

Email: tada1@mail.ru

PhD, assistant of the department

Russian Federation

Ivan Sergeevich Sadovsky

Federal State Budgetary Scientific Institution "Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" Separate Subdivision "Research Institute for Medical Problems of the North"

Email: sadovskii24@rambler.ru

junior researcher

Russian Federation

Elena Aleksandrovna Tsarkova

Federal State Budgetary Scientific Institution "Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" Separate Subdivision "Research Institute for Medical Problems of the North"

Email: service@axiomed.ru

research fellow

Russian Federation

Dmitry Aleksandrovich Kochenov

Federal State Budgetary Scientific Institution "Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" Separate Subdivision "Research Institute for Medical Problems of the North"

Email: dilail@yandex.ru

Ph.D., research fellow

Russian Federation

Alexander Gennadievich Borisov

Federal State Budgetary Scientific Institution "Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences" Separate Subdivision "Research Institute for Medical Problems of the North";
Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky" of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: 2885263@mail.ru

PhD, leading researcher

Russian Federation

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