Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology10010.31857/S102872210006587-0Research ArticleCOMPARATIVE ANALYSIS OF THE INDICATORS OF THE FUNCTIONAL ACTIVITY OF NEUTROPHILS PERIPHERAL BLOOD IN PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCKDolgushinI. I.<p>Ph.D. Professor of the department of Microbiology, Virology, Immunology and CLD, academician of RAS, honored scientist of the RF, president,</p><p>Chelyabinsk</p>fake@neicon.ruSavochkinaA. Y.<p>Ph.D. Professor of the department of Microbiology, Virology, Immunology and CLD,</p><p>Chelyabinsk</p>alina7423@mail.ruPykhovaL. R.<p>Senior laboratory assistant of the central research laboratory,</p><p>Chelyabinsk</p>fake@neicon.ruAbramovskihkO. S.<p>Ph.D. Professor of the department of Microbiology, Virology, Immunology and CLD,</p><p>Chelyabinsk</p>fake@neicon.ruChetverninaE. A.<p>Assistant of the department of Microbiology, Virology, Immunology and CLD,</p><p>Chelyabinsk</p>fake@neicon.ruPoltorakA. E.<p>doctor surgeon of surgical department № 1,</p><p>Chelyabinsk</p>fake@neicon.ruSouth Ural State Medical UniversityChelyabinsk Regional Clinical Hospital15042019222-12362381604202016042020Copyright © 2019, Dolgushin I.I., Savochkina A.Y., Pykhova L.R., Abramovskihk O.S., Chetvernina E.A., Poltorak A.E.2019<p>A comparative analysis of the functional activity of peripheral blood neutrophils in patients with sepsis, depending on the severity of the disease, has been carried out. An increase in the total number of leukocytes, neutrophil extracellular networks, indicators of neutrophil absorption activity and the activity of intracellular oxygen-dependent metabolism of neutrophils in patients with septic shock was detected.</p>severe sepsisseptic shockneutrophil extracellular trapsтяжелый сепсиссептический шокнейтрофильные внеклеточные ловушки[1. Shankar-Hari M., Phillips G. S., Levy M. L., Seymour C. W., Liu V. X., Deutschman C. S., Angus D. C., Rubenfeld G. D., Singer M. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). J.A.M.A. 2016, 315(8), 775–787.][2. Долгушин И. И., Торопова Л. Р., Савочкина А. Ю., Абрамовских О. С., Четвернина Е. А., Полторак А. Е. Динамика изменения показателей функциональной активности нейтрофилов у больных сепсисом с неблагоприятным исходом. Российский иммунологический журнал 2017, 11(20), 2, 295–296.][3. Brinkmann V., Rechard V., Goosmann C., Fauler B., Uhlemann Y., Weiss D. S., Weinrauch Y., Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science 2004, 303, 1532–1535.][4. Савочкина А. Ю., Пыхова Л. Р., Абрамовских О. С., Полторак А. Е., Четвернина Е. А. Сравнительный анализ показателей функциональной активности нейтрофилов периферической крови у больных с сепсисом в зависимости от исхода. Российский иммунологический журнал 2018, 12(21), 4, 407–411]