Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology16910.31857/S102872210006916-2Research ArticlePOLYMORPHISM OF ENZYMES OF BIOTRANSFORMATION OF XENOBIOTICS (GLUTATHIONE S-TRANSFERASES M1, T1, P1) IN PATIENTS WITH A COMBINATION OF ATOPIC DERMATITIS AND BRONCHIAL ASTHMAMolokovaA. V.<p>PhD, Department of Pediatrics, </p><p>Novosibirsk</p>fake@neicon.ruNovosibirsk state medical University15042019222-14174190605202006052020Copyright © 2019, Molokova A.V.2019<p>The study of polymorphism of glutathione S-transferases M1, T1, P1 in children with allergic diseases showed a predominance of mutant enzyme genotypes in severe atopic dermatitis and asthma. Genotypes GSTM1-, GSTT1- are signifi cant for the early formation of atopic dermatitis and bronchial asthma. Predisposition to combined atopy was registered for haplotypes M1+/T1-/P1ile105/Ile105 (OR=4.92; 95% CI 0.6736.53) (р0,05).</p>polymorphism of glutathiones transferase M1T1P1atopic dermatitisbronchial asthmaполиморфизм глутатион S-трансферазы M1T1P1атопический дерматитбронхиальная астма[1. Warholm M., Rane A., Alexandrie A. K. Genotypic and phenotypic determination of polymotphic glutathione transferase T1 in a Swedish population. Pharmacogenetics. 1995; 5, 252–254.][2. Zhong S., Wyllie A. H., Barnes D. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 1993; 14, 1821–1824.][3. Pemble S., Schroeder K. R., Spencer S. R. Human glutathione S-transferase Theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem. J. 1994; 300, Pt. 1, 271–276.]