Russian Journal of ImmunologyRussian Journal of ImmunologyРоссийский иммунологический журнал1028-72212782-7291Russian Society of Immunology1730410.46235/1028-7221-17304-BIAORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИUnknownBALANCING INFLAMMATION AND IMMUNE REGULATION IN PERI-IMPLANTITIS: INSIGHTS FROM THE PISF TNF-Α/IL-10 CYTOKINE RATIOhttps://orcid.org/0009-0007-3195-4092NajmAnsam Zuhair
Iraq

BDS., MSc., Oral Microbiology;

Assistant Lecturer in Department of Clinical Sciences, College of Dentistry, Al-Iraqia University, Baghdad, Iraq;

ansam.z@aliraqia.edu.iqhttps://orcid.org/0000-0001-8804-730258757514500https://www.researchgate.net/profile/Ehab-TalibTalibEhab Qasim
Iraq

BSc., MSc., Oral Microbiology and Clinical immunology

Assistant Lecturer in Department of Basic Sciences, College of Dentistry, Al-Iraqia University, Baghdad, Iraq;

ehab.q.t@aliraqia.edu.iqAl-Iraqia University, Baghdad, Iraq031220251908202525112025Copyright ©; , Najm A.Z., Talib E.Q.Copyright ©; , Najm A., Talib E.Najm A.Z., Talib E.Q.Najm A., Talib E.https://creativecommons.org/licenses/by/4.0https://rusimmun.ru/jour/article/view/17304

Background: Peri-implantitis is a severe inflammatory condition that affects both the hard and soft tissues around dental implants. It often results in progressive bone deterioration and eventually the failure of the implant. A crucial element in its development is the interaction between pro-inflammatory and anti-inflammatory cytokines in the local immune response. The ratio of tumour necrosis factor-alpha (TNF-α) to interleukin-10 (IL-10) has been suggested as a potential indication of this immunological balance.

Aim: To evaluate the diagnostic relevance of the TNF-α/IL-10 ratio in peri-implant sulcus fluid (PISF) for distinguishing peri-implantitis from healthy and successfully osseointegrated implants.

Materials and Methods: In this case control study, a total of 90 participants were recruited and divided into three equal groups: healthy controls, successful implant group, and peri-implantitis group. The clinical parameters in this study included Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP) and Probing Depth (PD). PISF samples were collected from all subject and TNF-α and IL-10 concentrations were measured using enzyme-linked immunosorbent assay (ELISA).

Results: The peri-implantitis group revealed significantly elevated levels of both TNF-α and IL-10 compared to the control group and successful implants (p < 0.001). The TNF-α/IL-10 ratio was significantly decreased in the peri-implantitis group (3.94 ± 1.22) compared to the control group (8.53 ± 1.56) and the successful implants group (7.92 ± 1.44) (p < 0.001).

Conclusion: The TNF-α/IL-10 ratio in PISF indicates the local inflammatory balance and may be an important biomarker for finding peri-implantitis. A lower ratio, together with higher cytokine levels, indicating an anti-inflammatory response that doesn't bring the immune system back to normal.

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