Russian Journal of ImmunologyRussian Journal of ImmunologyРоссийский иммунологический журнал1028-72212782-7291Russian Society of Immunology1733310.46235/1028-7221-17333-DUOREVIEWSОБЗОРЫUnknownDIAGNOSTIC UTILITY OF INFLAMMASOMES AMONG SUBJECTS WITH BOH IN POST-COVID-19Palakkattu VeetilAswathi
India

MSc

Research Scholar, Department of Microbiology and Immunology, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

aswathitharanath@gmail.comNallusamyDuraisamy
India

Ph.D

Assistant Professor/Research Scientist, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

drnallusamy@maher.ac.inRajendranGanapathy
India

Ph.D

Assistant Professor, Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Ramapuram, Chennai-89, Tamil Nadu, India

grajendrannrm@gmail.comSenthamaraiSrinivasan
India

MBBS, MD

Professor and HOD, Department of Microbiology, Meenakshi Medical College Hospital and Research Institute, Enathur, Kanchipuram, Tamil Nadu, India

thamaraimicro@gmail.comMullukalayil JosephSheeja
India

MSc

Research Scholar, Department of Biochemistry, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

srsudhanyamsj@gmail.comKrishnanPriyanka
India

MSc

Research Scholar, Department of Pathology, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

priya.priyankakrishnan@gmail.comNellikuzhimalayil ParameswaranNitha
India

MSc

Research Scholar, Department of Anatomy, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

nithajijo1982@gmail.comJoseJeena
India

MSc

Research Scholar, Department of Anatomy and Molecular Biology, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

jeena.j.joy@gmail.comRoy DivakaranDinesh
India

Ph.D

CEO & Senior Cytogeneticist, Genetika Centre for Advanced Genetic Studies, Thiruvananthapuram, Kerala, India

drdineshroyd@gmail.comMeenakshi Academy of Higher Education (Deemed to be university) Chennai, Tamil Nadu, IndiaSRM Institute of Science and Technology, Ramapuram, Tamil Nadu, IndiaMeenakshi Medical College Hospital and Research Institute, Enathur,Kanchipuram, Tamil Nadu, IndiaGenetika Centre for Advanced Genetic Studies, Thiruvananthapuram, Kerala, India021220251010202525112025Copyright ©; , Palakkattu Veetil A., Nallusamy D., Rajendran G., Senthamarai S., Mullukalayil Joseph S., Krishnan P., Nellikuzhimalayil Parameswaran N., Jose J., Roy Divakaran D.Copyright ©; , Palakkattu Veetil A., Nallusamy D., Rajendran G., Senthamarai S., Mullukalayil Joseph S., Krishnan P., Nellikuzhimalayil Parameswaran N., Jose J., Roy Divakaran D.Palakkattu Veetil A., Nallusamy D., Rajendran G., Senthamarai S., Mullukalayil Joseph S., Krishnan P., Nellikuzhimalayil Parameswaran N., Jose J., Roy Divakaran D.Palakkattu Veetil A., Nallusamy D., Rajendran G., Senthamarai S., Mullukalayil Joseph S., Krishnan P., Nellikuzhimalayil Parameswaran N., Jose J., Roy Divakaran D.https://creativecommons.org/licenses/by/4.0https://rusimmun.ru/jour/article/view/17333

The diagnostic utility of inflammasomes in Bad Obstetric History (BOH) following COVID-19 remains a critical area of investigation. COVID-19, which emerged in late 2019, and was caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has globally impacted health. The virus primarily targets Angiotensin-Converting Enzyme2 (ACE2) receptors, with elevated expression in various organs. Inflammasomes, integral to innate immunity, play a pivotal role in regulating proinflammatory responses, culminating in the release of cytokines and gasdermin-D-mediated pyroptosis. The pathophysiology of COVID-19 involves systemic inflammation, leading to a cytokine surge and instances of post-infectious Multi-system Inflammatory Syndrome (MIS). Diagnostic insights into inflammation post-COVID-19 rely on biomarkers such as IL-6, TNF-α and reactive oxygen species, with molecular probes facilitating imaging. A rigorous literature review was conducted using databases like PubMed, Google Scholar, Scopus, and Web of Science, focusing on studies (2015-2023) related to inflammasomes, proinflammatory cytokines, and serum markers in BOH post-COVID-19. Data from 76 selected articles were systematically extracted, categorized, and analyzed to identify diagnostic patterns and therapeutic interventions. The findings were synthesized into a manuscript emphasizing the diagnostic utility of inflammasomes, with multiple refinements ensuring clarity and scientific rigor. Exploring inflammasomes in BOH post-COVID-19 is promising, as inflammation and cytokine surges suggest their diagnostic potential. Further research is needed to confirm their role and improve diagnostic strategies for viral-induced inflammatory outcomes. This review explores the potential diagnostic significance of inflammasomes among subjects with BOH following COVID-19, emphasizing the need for a comprehensive understanding of the inflammatory processes associated with this unique clinical scenario.

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