Russian Journal of ImmunologyRussian Journal of ImmunologyРоссийский иммунологический журнал1028-72212782-7291Russian Society of Immunology1735110.46235/1028-7221-17351-IISREVIEWSОБЗОРЫUnknownIMMUNOTHERAPY IN SPECIFIC AUTOIMMUNE DISEASESKaurSifat
India
sifat22092.ccp@chitkara.edu.inVermaReetreet22082.ccp@chitkara.edu.inJhakarManju
India
manju.jakhar@baddiuniv.ac.inRaniDr. Nidhi
India
nidhiprajapati8@gmail.comSinghThakur Gurjeet
India
gurjeetthakur@gmail.comChitkara University, Punjab, IndiaBaddi University of emerging sciences and technology, Baddi, H.P., India050220260412202518012026Copyright ©; , Rani D., Kaur S., Verma R., Jhakar M., Singh T.Copyright ©; , Rani D., Kaur S., Verma R., Jhakar M., Singh T.Rani D., Kaur S., Verma R., Jhakar M., Singh T.Rani D., Kaur S., Verma R., Jhakar M., Singh T.https://creativecommons.org/licenses/by/4.0https://rusimmun.ru/jour/article/view/17351

The gold standard for treating autoimmune illnesses now consists of biological medications as well as small molecule inhibitors that target immune cells, inflammatory cytokines, and intracellular kinases. The therapy of autoimmune conditions like psoriasis, ankylosing spondylitis, and rheumatoid arthritis can be cured by the suppression of TNF, IL-6, IL-17, and IL-23. Anti-CD20 mAb-based B cell depletion therapy has demonstrated encouraging outcomes in subjects with neuroinflammatory disorders, and lupus can be cured by blocking B cell survival factors. By altering T lymphocyte activity, aiming co-stimulatory entities uttered on antigen-revealing cells and T lymphocyte is found to exhibit healing properties in auto-immune disorders. In the realm of autoimmune and hematologic disorders, small entity kinase inhibitors that target the JAK family have recently attracted a lot of attention. Regarding therapeutic effectiveness and safety profiles, there are still unmet medical demands, nonetheless. Emerging treatments use cutting- edge molecular engineering methods to create immunological tolerance without impairing immune function.

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