Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology18210.31857/S102872210006929-6Research ArticleFEATURES CIRCULATING PRO- AND ANTITUMOR MONOCYTES IN PATIENTS WITH TRIPLE NEGATIVE BREAST CANCERPatyshevaM. R.<p>MD, Clinical Laboratory Scientist of Cancer Research Institute,</p><p>Tomsk</p>starin5@yandex.ruStakheyevaM. N.<p>PhD, Leading Researcher of Cancer Research Institute,</p><p>Tomsk</p>fake@neicon.ruFedorovA. A.<p>student,</p><p>Tomsk</p>fake@neicon.ruTarabanovskayaN. A.<p>MD, PhD, Researcher of Cancer Research Institute, </p><p>Tomsk</p>fake@neicon.ruGrigorievaE. S.<p>PhD, Junior Researcher of Cancer Research Institute,</p><p>Tomsk</p>fake@neicon.ruSlonimskayaE. M.<p>MD, PhD, Head of the general oncology,</p><p>Tomsk</p>fake@neicon.ruKzhyshkowskaJ. G.<p>PhD, Professor of Tomsk State University, the Head of the laboratory of translational cellular and molecular biomedicine,</p><p>Tomsk</p>fake@neicon.ruCherdyntsevaN. V.<p>PhD, Head of the laboratory of molecular oncology and immunology;</p><p>the Leading Researcher of laboratory of translational cellular and molecular biomedicine, </p><p>Tomsk</p>fake@neicon.ruCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of SciencesTomsk State UniversitySiberian State Medical University15042019222-14594611205202012052020Copyright © 2019, Patysheva M.R., Stakheyeva M.N., Fedorov A.A., Tarabanovskaya N.A., Grigorieva E.S., Slonimskaya E.M., Kzhyshkowska J.G., Cherdyntseva N.V.2019<p>Phenotypic markers of pro- and antitumor polarization of blood monocytes in patients with a triple negative breast cancer were characterized in this work. This molecular subtype differed from the luminal B and Her2+ subtypes in the content of CD163+, stabilized-1+ and HLA-DR+ circulating monocytes. The identified differences can be used as a differential diagnostic marker for a triple negative breast cancer subtype.</p>monocytespro- and antitumor polarizationtriple negative breast cancerмоноцитыпро- и противоопухолевая поляризациятрижды негативный подтип рака молочной железы[1. Bianchini G., Balko J. M., Mayer I. A., Sanders M. E., Gianni L. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol. 2016 Nov;13(11):674–690.][2. Zhang B., Cao M., He Y., Liu Y., Zhang G., Yang C., Du Y., Xu J., Hu J., Gao F. Increased circulating M2- like monocytes in patients with breast cancer. Tumour Biol. 2017; 39(6):1010428317711571.]