Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology18310.31857/S102872210006930-8Research ArticleEFFECTS OF CARBOPLATIN WITH CUCURBIT[7]URIL ON SUBPOPULATION COMPOSITION AND PROLIFERATIVE ACTIVITY OF LYMPHOCYTES IN VITROPashkinaE. A.<p>PhD, Researcher, Clinical Immunopathology Laboratory;</p><p>Assistant of the Department of Clinical Immunology at the Medical Faculty,</p><p>Novosibirsk</p>pashkina.e.a@yandex.ruAktanovaA. A.<p>six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,</p><p>Novosibirsk</p>fake@neicon.ruErmakovA. A.<p>six-year student of the Faculty of Medicine and Prevention of the specialty of Medical Biophysics,</p><p>Novosibirsk</p>fake@neicon.ruKnauerN. Yu.<p>PhD student, Clinical Immunopathology Laboratory,</p><p>Novosibirsk</p>fake@neicon.ruMirzaevaI. V.<p>PhD, Researcher, Laboratory of Condensed Matter Physical Chemistry, </p><p>Novosibirsk</p>fake@neicon.ruKovalenkoE. A.<p>PhD, Researcher, Laboratory of cluster and supramolecular chemistry,</p><p>Novosibirsk</p>fake@neicon.ruFSBSI “Research Institute of Fundamental and Clinical Immunology”Novosibirsk State Medical UniversityInstitute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences15042019222-14624641205202012052020Copyright © 2019, Pashkina E.A., Aktanova A.A., Ermakov A.A., Knauer N.Y., Mirzaeva I.V., Kovalenko E.A.2019<p>It is known that the use of delivery systems can reduce the toxicity of platinum compounds without losing a high therapeutic effect. In this work, the immunotoxic effect of carboplatin when co-added with cucurbit[7]uril was investigated, including the effect on the subpopulation composition of lymphocytes and their proliferative activity in vitro.</p>cucurbit[7]urilcarboplatinantitumor therapylymphocytesкукурбит[7]урилкарбоплатинпротивоопухолевая терапиялимфоциты[1. Wheate N. J. Improving platinum (II)-based anticancer drug delivery using cucurbit [n] urils. Journal of inorganicbiochemistry. 2008, 102, 2060–2066.][2. Mirzaeva I. V., Moroz N. K., Andrienko I. V., Kovalenko E. A. Interaction between carboplatin and cucurbit[7]uril studied by means of multinuclear NMR spectroscopy and DFT calculations J. Mol. Struct. 2018, 1163, 68–76.][3. Актанова А. А., Ермаков А. А., Пашкина Е. А. Сравнительный анализ противоопухолевого и иммунотоксического действия комплекса кукурбит[7] урила с карбоплатином. Российский иммунологический журнал. 2018, 12(21), 595–597.]