Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology2010.31857/S102872210006425-2Research ArticleINFLUENCE OF OZONOTHERAPY ON IMMUNE STATUS AT ISOLATED FRACTURES OF THE FEMORAL BONEAbramovK. S.<p>Senior Laboratory Assistant, Department of Pathological Physiology, </p><p>Chelyabinsk</p>prof.osikov@yandex.ruDavydovaE. V.<p>MD, associate professor, professor of the Department of Pathological Physiology, </p><p>Chelyabinsk</p>fake@neicon.ru“South Ural State Medical University” of the Ministry of Health of Russia15042019222-11301310304202003042020Copyright © 2019, Abramov K.S., Davydova E.V.2019<p>The study of the functional activity of blood monocytes under conditions of ozone therapy for isolated femoral fractures showed that post-traumatic femoral fractures are accompanied by functional activation of cells of the innate compartment of the immune system in the form of increased adhesive and bactericidal activity. The use of ozone therapy in the form of a small autohemotherapy procedure increases the level of monocyte functional activity, contributing to the activation of wound cleansing processes and the prevention of infectious complications.</p>femur fracturefunctional activity of monocytesozone therapyперелом бедренной костифункциональная активность моноцитовозонотерапия[1. Amarante-Mendes G. P., Adjemian S., Branco L. M. Pattern Recognition Receptors and the Host Cell Death Molecular Machinery. Front Immunol. 2018, 9:2379. doi: 10.3389/fimmu.2018.02379.][2. Netea M. G. A guiding map for infl ammation. Nat Immunol. 2017, 18, 826–831.][3. Gibon E., Lu L. Y., Nathan K., Goodman S. B. Inflammation, ageing, and bone regeneration. J Orthop Translat. 2017, 10, 28–35. doi: 10.1016/j.jot.2017.04.002.]