Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology20510.31857/S102872210006952-2Research ArticleANTIMICROBIAL PEPTIDES IN THE TREATMENT OF MUSCULAR ORAL CAVITYSarkisyanN. G.<p>candidate of medical sciences, assistant, department of therapeutic dentistry and propedeutics of dental diseases, </p><p>Ekaterinburg</p>narine_25@mail.ruKataevN. N.<p>candidate of chemical sciences, assistant professor department of general chemistry,</p><p>Ekaterinburg</p>fake@neicon.ruTuzankinaI. A.<p>doctor of medicine, professor, </p><p>Ekaterinburg</p>fake@neicon.ruMelikyanS. G.<p>student,</p><p>Ekaterinburg</p>fake@neicon.ruUral state medical university of the ministry of health of the Russian FederationInstitute of Immunology and Physiology Ural detachment of the Russian Academy of Sciences15042019222-15245261805202018052020Copyright © 2019, Sarkisyan N.G., Kataev N.N., Tuzankina I.A., Melikyan S.G.2019<p>Antimicrobial peptides are the most promising drugs in the replacement of antibiotic therapy. The results of the analysis of the physicochemical properties of Atsegram spray, in particular, surface tension (, Erg / cm2) and conductivity (, S / cm) show the relationship with the mechanism of the antibacterial action of the drug and its eff ectiveness in the treatment of periodontitis. Spray application revealed an improvement in the hygienic condition of the oral cavity by a factor of 1.4, a decrease in the PMA index by 1.8 times, a decrease in the bleeding index of the gingival margin by a factor of 2 a month after treatment compared with the same indicators of the comparison group undergoing standard treatment.</p>disease of the oral mucosaperiodontitissynthetic peptidephysicochemical propertiesantibacterial actionзаболевание слизистой полости ртапародонтитсинтетический пептидфизико-химические свойстваантибактериальное действие[1. Ронь Г. И. Инновационные технологии в диагностике и лечении воспалительных заболеваний пародонта. Екатеринбург, УГМА, 2011, 276 с.][2. Мусин Х. Г. Антимикробные пептиды – потенциальная замена традиционным антибиотикам // Инфекция и иммунитет. 2018.Т.8, № 3.С.295–308.][3. Слесарев В. И. Химия: Основы химии живого. Учебник для вузов, Химиздат, 2017, 784 с.][4. Hancock R. E.W., Sahl H.-G. Antimicrobial and hostdefense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol., 2006, vol. 24, pp. 1551–1557. doi: 10.1038/nbt1267]