Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology23510.31857/S102872210006989-2Research ArticleSTANDARD TREATMENT IN THE CORRECTION OF IMMUNE DISTURBANCES IN ACUTE SEROUS AND PURULENT PYELONEPHRITISKholimenkoI. M.<p>Department of Urology,</p><p>Kursk</p>kholimenko@yandex.ruShatohinM. N.<p>Professor of the Department of endoscopic urology,</p><p>Moscow</p>fake@neicon.ruMaltsevV. N.<p>Department of Urology,</p><p>Kursk</p>fake@neicon.ruKotsarA. G.<p>Department of Urology,</p><p>Kursk</p>fake@neicon.ruEmelyanovaE. S.<p>student,</p><p>Kursk</p>fake@neicon.ruKursk State Medical UniversityDepartment of Endoscopic Urology, Russian Medical Academy of Continuous Professional Education of Minzdrav of Russia15042019222-16116132105202021052020Copyright © 2019, Kholimenko I.M., Shatohin M.N., Maltsev V.N., Kotsar A.G., Emelyanova E.S.2019<p><strong>Objective:</strong> to study the eff ectiveness of the basic treatment of acute pyelonephritis in terms of immune status.</p>
<p><strong>Materials and methods</strong>. The immune status of 62 patients with various forms of acute pyelonephritis.</p>
<p><strong>Results.</strong> and its discussion. When serous and purulent forms of acute pyelonephritis are observed: increased levels of cytokines with a decrease in anti-infl ammatory with purulent pyelonephritis and their imbalance ‒ with serous form, an imbalance in the complement system, increased production of immunoglobulins with a simultaneous decrease in CIC, reduced activity and intensity of phagocytosis in the background of increased metabolic activity.</p>
<p><strong>Conclusion.</strong>With serous and purulent forms of pyelonephritis, there are diff erences in the direction and severity of changes in immune parameters that do not normalize after treatment, which requires the development of additional methods of immunocorrection and immunorehabilitation.</p>immune statusbasic treatmentacute serous and purulent pyelonephritisиммунный статусбазисное лечениеострый серозный и гнойный пиелонефрит[1. Холименко И. М., Конопля А. И., Братчиков О. И., Быстрова Н. А., Маврин М. Ю., Шатохин М. Н. Оксидантный cтресс при остром серозном и гнойном пиелонефрите // Нефрология. –2017. – Т. 21. № 1. С. 87–94.][2. Spits H., Artis D., Colonna M. Innate lymphoid cells – aproposal for a uniform nomenclature // Nat. Rev. Immunol. 2013. Vol. 13. – P. 145–149.][3. Холименко И. М., Братчиков О. И., Джаримок А. Р., Шатохин М. Н., Маврин М. Ю., Быстрова Н. А. Лабораторная эффективность стандартного лечения при остром серозном и гнойном пиелонефрите. Курский научно-практический вестник «Человек и его здоровье». 2016; 1:62–68.][4. Choong F. X., Antypas H. L., Richter-Dahlfors A. Integrated Pathophysiology of Pyelonephritis // Microbiol Spectr. – 2015.]