Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology25510.31857/S102872210007008-3Research ArticleCLINICO-IMMUNOLOGICAL EVALUATION OF THE EFFECTIVENESS OF INTRAVENOUS IMMUNOGLOBULINS AS AN ADJUVANT THERAPY FOR SURGICAL SEPSISShumatovV. B.<p>Doctor of Sciences, Professor of the Department of intensive care, anesthesiology, intensive care and emergency medical services,</p><p>Vladivostok</p>fake@neicon.ruLazanovichV. A.<p>Ph.D., assistant professor, Department of normal and Pathological Physiology,</p><p> </p>immuno2003@mail.ruKrasnikovV. E.<p>Ph.D., assistant professor, Department of normal and Pathological Physiology,</p><p>Vladivostok</p>fake@neicon.ruState budget educational institute of higher professional education Pacific State MedicalUniversity of Ministry of health Russian Federation15042019222-16666682605202026052020Copyright © 2019, Shumatov V.B., Lazanovich V.A., Krasnikov V.E.2019<p>We observed 46 patients with sepsis, which were divided into 2 groups. I group (25 patients) received traditional treatment, II group (21 patients) in addition to conventional therapy received enriched IVIG (IgM+IgA). Comparative assessment of the combination of intravenous immunoglobulins and traditional therapy indicated the clinical effectiveness of IVIG therapy, which results in reducing the severity of systemic inflammation, the severity of the disease and the mortality in patients with surgical sepsis.</p>intensive therapyintravenous immunoglobulinssepsisинтенсивная терапиявнутривенные иммуноглобулинысепсис[1. Busani S., Damiani E., Cavazzuti I. Intravenous immunoglobulin in septic shock: review of the mechanisms of action and meta-analysis of the clinical effectiveness. Minerva Anestesiol. 2016. Vol. 82. P. 559–572.][2. Шуматов В. Б., Лазанович В. А., Павлов В. А., Ермакова Н. Д., Просекова Е. В. Внутривенные иммуноглобулины в адъювантной терапии сепсиса. Тихоокеанский медицинский журнал, 2017. № 242 С. 42–45.]