Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology2910.31857/S102872210006433-1Research ArticleABILITY OF CONDITIONALLY-PATHOGENIC MICROORGANISM TO INACTIVATE ANTI-MICROBIAL PROTEIN BY LYSOZYM UNDER THE INFLUENCE OF METABOLITES ASSOCIATION OF BIFIDOBACTERIABekpergenovaA. V.<p>Researcher, Laboratory of Biomonitoring and Molecular Genetic Research,</p><p>Orenburg</p>nsavasteeva@gmail.comPerunovaN. B.<p>PhD, Professor RAS, Associate Professor Laboratory of Biomonitoring and Molecular Genetic Research, </p><p>Orenburg</p>fake@neicon.ruAndryushenkoS. V.<p>PhD, Associate Professor Laboratory of Biomonitoring and Molecular Genetic Research,</p><p>Orenburg</p>fake@neicon.ruZdvizhkovaI. A.<p>Researcher, Laboratory of Biomonitoring and Molecular Genetic Research,</p><p>Orenburg</p>fake@neicon.ruMironovaA. R.<p>Head of Bacteriological Laboratory, </p><p>Orenburg</p>fake@neicon.ruFGBUN Institute for Cellular and Intracellular SymbiosisGBUZ Orenburg Regional Clinical Infectious Diseases Hospital, Orenburg15042019222-11561581104202011042020Copyright © 2019, Bekpergenova A.V., Perunova N.B., Andryushenko S.V., Zdvizhkova I.A., Mironova A.R.2019<p>Materials on the eff ect of the supernatants of the associations of bifi dobacteria on the antilysozyme activity of microorganisms are presented. An increase in the antilysozyme activity was detected in the lactosopositive non-hemolytic strains of E. coli isolated during human intestinal eubiosis, and, conversely, a decrease in hemolytic E. coli, S. aureus and C. albicans isolated in dysbiosis. The available materials contribute to the study of the mechanisms of formation of microsymbiosis in the associative symbiosis of humans and contribute to the identifi cation of strains of bifi dobacteria, suitable as pro- and metabiotics.</p>lysozymepersistenceantilysozyme activitybifi dobacteriamicrobial associationseubiosisdysbiosisprobioticsлизоцимперсистенцияантилизоцимная активностьбифидобактериимикробные ассоциацииэубиоздисбиозпробиотики[1. Бухарин О. В. Персистенция патогенных бактерий. М.: Медицина, 1999, 322.][2. Шендеров Б. А. Медицинская микробная экология и функциональное питание. М.: ГАРАНТЪ. 1998, 1, 288.]