Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology29510.31857/S102872210006704-9IMBALANCE IN THE CONTENT OF CYTOKINES AND GROWTH FACTORS IN THE INTRAOCULAR FLUID IN PRIMARY OPEN-ANGLE GLAUCOMAErmakovaO. V.oven_e@mail.ruOrlovN. B.fake@neicon.ruTrunovA. N.fake@neicon.ruKonenkovV. I.fake@neicon.ruChernykhV. V.fake@neicon.ruThe academician S. N. Fyodorov Federal State Institution National Medical Research Center «Intersectoral Research and Technology Complex «Eye microsurgery» Ministry of Health of the Russian Federation»Scientific Research Institute of Clinical and Experimental Lymphology – a branch of Federal Research Center of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»Federal Research Center for Fundamental and Translational Medicine of the Siberian Branch of the Russian Academy of Sciences»15072019222-27697710306202003062020Copyright © 2019, Ermakova O.V., Orlov N.B., Trunov A.N., Konenkov V.I., Chernykh V.V.2019Was shown increase in the concentrations of cytokines and growth factors (IL-4, IL-6, IL-8, IL-17, TGF-β -1, 2, 3, macrophage infl ammatory protein – 1beta) in the intraocular fluid of patients withdevelopedstage of the primary open-angle glaucoma. This indicates that in the pathogenesis of primary open-angle glaucoma, the activity of the local chronic inflammatory process is determined.Primary open-angle glaucomaintraocular fluidcytokinesgrowth factorsпервичная открытоугольная глаукомавнутриглазная жидкостьцитокиныфакторы роста[1. Черных В. В., Бгатова Н. П., Орлов Н. Б., Ермакова О. В., Трунов А. Н. Местный воспалительный процесс при глаукоме как возможное проявление нарушений увеолимфатического оттока внутриглазной жидкости при глаукоме. Национальный журнал глаукома. 2018. 17(2). 3–11.][2. Junglas B., Kuespert S., Seleem A. A., Struller T., Ullmann S., Bösl M., Bosserhoff A., Köstler J., Wagner R., Tamm E. R., Fuchshofer R.Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork Am. J. Pathol. 2012. 180(6). 2386–2403.][3. Kokubun T., Tsuda S., Kunikata H., Yasuda M., Himori N., Kunimatsu-Sanuki S., Maruyama K., Nakazawa T. Characteristic profiles of inflammatory cytokines in the aqueous humor of glaucomatous eyes. Ocul. Immunol. Infl amm. –2017. 16. 1–12.][4. Tong Y., Zhou Y. L., Zheng Y., Biswal M., Zhao P. Q., Wang Z. Y. Analyzing cytokines as biomarkers to evaluate severity of glaucoma. Int. J. Ophthalmol. – 2017. 10(6). 925–930.]