Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology310.31857/S102872210005015-1Research ArticleABOUT THE NAKED MOLE RAT LYMPHOID TISSUESGorshkovaE. A.<p>PhD student, Department of Immunology, Biological Faculty,</p><p>Moscow</p>gorshsama@gmail.comGubernatorovaE. O.<p>PhD student, Department of Immunology, Biological Faculty, </p><p>Moscow</p>fake@neicon.ruMedvedovskayaA. D.<p>student, Department of Immunology, Biological Faculty, </p><p>Moscow</p>fake@neicon.ruVyssokikhM. Yu.<p>PhD (Biology), head of laboratory, </p><p>Moscow</p>fake@neicon.ruHoltzeS.<p>scientist, Department of Reproduction Management, </p><p>Berlin</p>fake@neicon.ruHildebrandtT. B.<p>Professor, head of Reproduction Management Department, </p><p>Berlin</p>fake@neicon.ruDrutskayaM. S.<p>PhD (Biology), leading researcher, </p><p>Moscow</p>fake@neicon.ruNedospasovS. A.<p>MD (Biology), Professor, academician, head of Department of Immunology, Biological Faculty;</p><p>head of laboratory;</p><p>head of laboratory, </p><p>119334, Moscow, Vavilova srt., 32.</p>sergei.nedospasov@gmail.comLomonosov Moscow State UniversityEngelhardt Institute of Molecular Biology, Russian Academy of SciencesBelozersky Institute of PhysicoChemical Biology, Lomonosov Moscow State UniversityBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State UniversityLeibniz-Institute for Zoo and Wildlife Research150120192215122503202025032020Copyright © 2019, Gorshkova E.A., Gubernatorova E.O., Medvedovskaya A.D., Vyssokikh M.Y., Holtze S., Hildebrandt T.B., Drutskaya M.S., Nedospasov S.A.2019<p>The naked mole-rat (Heterocephalus glaber) is an eusocial rodent living underground, known for its unusually high life expectancy. Biochemical markers of age associated diseases (cancer, neurodegenerative diseases) in naked mole-rat are less pronounced than in other laboratory rodents. The immune system is involved in the aging and carcinogenesis regulation, however, the immune system in the naked mole-rats is yet not investigated well. We found that the immune system of naked mole-rats has structural diff erences compared to a mouse immune system: a smaller number of the bone marrow cells and splenocytes, the small size of the lymphoid follicles of the spleen and lymph nodes, a higher proportion of myeloid cells in the periphery. Taken together, these data provide a basis for studying the fundamental immunity patterns of the naked mole rat, and their contribution to the extraordinary longevity.</p>naked mole ratimmunomorphologymyeloid cellsmodel of healthy agingголый землекопморфология иммунной системымиелоидные клеткимодели старения[1. Jarvis J. U. 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