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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "https://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Immunology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Immunology</journal-title><trans-title-group xml:lang="ru"><trans-title>Russian Journal of Immunology</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1028-7221</issn><issn publication-format="electronic">2782-7291</issn><publisher><publisher-name xml:lang="en">Russian Society of Immunology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">341</article-id><article-id pub-id-type="doi">10.31857/S102872210006686-9</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">CYTOKINES IN THE PATHOGENESIS OF SPONTANEOUS URTICARIA</article-title><trans-title-group xml:lang="ru"><trans-title>ЦИТОКИНЫ В ПАТОГЕНЕЗЕ СПОНТАННОЙ КРАПИВНИЦЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Krivonkina</surname><given-names>A. E.</given-names></name><name xml:lang="ru"><surname>Кривонкина</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>allergist-immunologist,</p><p>Petrozavodsk</p></bio><bio xml:lang="ru"><p>врач аллерголог-иммунолог,</p><p>185031 Республика Карелия, Петрозаводск, ул. Кирова, д. 40</p></bio><email>Krivonkina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yudina</surname><given-names>S. M.</given-names></name><name xml:lang="ru"><surname>Юдина</surname><given-names>С. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor of medical sciences, professor, Head of the Department of Clinical Immunology, Allergology and Phthisiopulmonology</p><p>Petrozavodsk</p></bio><bio xml:lang="ru"><p>д. м. н., профессор, зав. кафедрой клинической иммунологии, аллергологии и фтизиопульмонологии,</p><p>Петрозаводск</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bahirev</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Бахирев</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, docent, Department of Faculty Therapy, Phthisiology, Infectious Diseases and Epidemiology,</p><p>Petrozavodsk</p></bio><bio xml:lang="ru"><p>к. м. н., доцент кафедры факультетской терапии, фтизиатрии, инфекционных болезней и эпидемиологии,</p><p>Петрозаводск</p></bio><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">State Budget Institution of Health Care of the Republic of Karelia “Emergency Hospital”</institution></aff><aff><institution xml:lang="ru">ГБУЗ РК «Больница скорой медицинской помощи»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Federal State Budget Educational Institution of Higher Education “Kursk State Medical University”</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Курский государственный медицинский университет» Минздрава РФ</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Federal State Budget Educational Institution of Higher Education “Petrozavodsk State University” Medical Institute</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Петрозаводский государственный университет», медицинский институт</institution></aff></aff-alternatives><content-language>ru</content-language><pub-date date-type="pub" publication-format="electronic" iso-8601-date="2019-07-15"><day>15</day><month>07</month><year>2019</year></pub-date><pub-date date-type="collection"><year>2019</year></pub-date><volume>22</volume><issue>2-2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>819</fpage><lpage>821</lpage><history><date date-type="received" iso-8601-date="2020-06-09"><day>09</day><month>06</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-06-09"><day>09</day><month>06</month><year>2020</year></date></history><pub-history><event event-type="received"><event-desc>Received:<date date-type="received" iso-8601-date="2020-06-09"><day>09</day><month>06</month><year>2020</year></date></event-desc></event><event event-type="accepted"><event-desc>Accepted:<date date-type="accepted" iso-8601-date="2020-06-09"><day>09</day><month>06</month><year>2020</year></date></event-desc></event><event event-type="pub"><event-desc>Published:<pub-date date-type="pub" publication-format="electronic" iso-8601-date="2019-07-15"><day>15</day><month>07</month><year>2019</year></pub-date></event-desc></event></pub-history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Krivonkina A.E., Yudina S.M., Bahirev A.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Кривонкина Е.А., Юдина С.М., Бахирев А.М.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Krivonkina A.E., Yudina S.M., Bahirev A.M.</copyright-holder><copyright-holder xml:lang="ru">Кривонкина Е.А., Юдина С.М., Бахирев А.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rusimmun.ru/jour/article/view/341">https://rusimmun.ru/jour/article/view/341</self-uri><abstract xml:lang="en"><p>IL-4 and TNFα cytokines are involved in the pathogenesis of spontaneous urticaria and can be considered as potential biomarkers of the disease.</p></abstract><trans-abstract xml:lang="ru"><p>Цитокины IL-4, и TNFα принимают участие в патогенезе спонтанной крапивницы и могут рассматриваться в дальнейшем как потенциальные биомаркеры заболевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>urticaria</kwd><kwd>cytokines</kwd><kwd>serum IgE</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>крапивница</kwd><kwd>цитокины</kwd><kwd>сывороточный IgE</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. 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