Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology34210.31857/S102872210006685-8REACTION OF CELLULAR FACTORS IN INNATE AND ADAPTIVE IMMUNITY OF THE PIGLETS ON THE INTRODUCTION OF THE DRUG «ANANDIN»КryachkoO. V.<p>Dr., Prof., Head of the Department of Pathological Physiology,</p><p>Sankt-Petersburg</p>pathophys-spbgavm@yandex.ruKhomenkoR. M.<p>Ph.D., Assistant, Department of Pathological Physiology,</p><p>Sankt-Petersburg</p>fake@neicon.ruSt. Petersburg State Academy of Veterinary Medicine15072019222-28228241006202010062020Copyright © 2019, Кryachko O.V., Khomenko R.M.2019<strong>The purpose of this study</strong> is to study the eff ect of the drug “Anandin” on some cellular factors of innate and adaptive immunity in piglets. “Anandin” is a drug from the group of immunomodulators that contains two types of compounds, these are derivatives of acridone acetic acid, as well as nitrogencontaining a-D-glucofurase. For the experiment, 30 piglets were selected 15 days before weaning (40 days old). The mass and physiological state of the animals was the same. The study involved a single administration of 10% solution “Anandin” experimental group of animals at a dose of 15 mg/kg body weight. The control group was intact. Before and after the introduction of the drug were carried out laboratory blood tests. The results showed that “Anandin” has a positive eff ect on the performance of cellular factors of immunity. The parameters studied: the activity of oxygen-dependent and oxygen-independent bactericidal systems of neutrophils (LKT and NBT-stimulated), production of lymphokines in RTML, removal of antigens (level of circulating immune complexes).innate immunityadaptive immunitycellular factors“Anandin”pigsврожденный иммунитетадаптивный иммунитетклеточные факторы«Анандин»поросята[1. Смоленцев С. Ю., Роженцов А. Л., Александров Ю. А. Влияние иммуностимуляторов на формирование иммунитета у свиноматок и поросят //Ученые записки Казанской государственной академии ветеринарной медицины им. Н. Э. Баумана. 2012. Т. 210. С. 215–220.][2. Хоменко Р. М. Ветеринарно-гигиеническая оценка использования «Анандина» на свиноматках и поросятах: дис…канд. вет.наук. Санкт-Петербург, 2006. –107 с.][3. Takamatsu H.-H., Denyer M. S., Stirling C. M.A., Netherton C. L., Oura C. A.L., Lacasta A., Argilaguet J. M., Rodríguez F., Martins C. Cellular immunity in ASFV responces // Virus Research. 2013. Т. 173. № 1. P. 110–121.][4. Методические рекомендации по проведению иммунологических исследований: Методы оценки Т- и В-систем иммунитета/ Воен.-мед. акад. Подгот. В. Г. Морозов, В. Х. Хавинсон. – Л., 1980. – 43 с.][5. Хоменко Р. М., Крячко О. В., Лукоянова Л. А. Влияние препарата «Анандин»® на некоторые иммунологические показатели у свиноматок в период супоросности и лактации.// Международный вестник ветеринарии. 2018. № 3. С. 58–62.]