Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology35510.31857/S102872210006682-5COMPARATIVE CHARACTERISTICS OF THE INDICES OF SYSTEMIC IMMUNITY AND SKIN IMMUNITY BEFORE AND AFTER THE PROCEDURE OF BIOREVITALIZATIONKudrevichY. V.<p>Candidate of Medical Science, Associate Professor of the Department of Dermatovenereology,</p><p>Chelyabinsk</p>fake@neicon.ruKuznetsovaE. K.<p>Candidate of Medical Science, Assistant of the Department of Dermatovenereology,</p><p>Chelyabinsk</p>cyton@rambler.ruZiganshinO. R.<p>d. m. s., Professor, Head of the Department of Dermatovenereology,</p><p>Chelyabinsk</p>fake@neicon.ruSychugovG. V.<p>Candidate of Medical Science, Assistant of the Department of Pathological Anatomy and Forensic Medicine,</p><p>Chelyabinsk</p>fake@neicon.ruZayatsT. A.<p>esident of the Department of Pathological Anatomy and Forensic Medicine,</p><p>Chelyabinsk</p>fake@neicon.ruEmelinaA. I.<p>resident of the Department of Pathological Anatomy and Forensic Medicine,</p><p>Chelyabinsk</p>fake@neicon.ruFederal State Budget Educational Institution of Higher Education “South Ural State Medical University” of the Ministry of Health of the Russian FederationFederal State Budget Educational Institution of Higher Education “Orenburg State Medical University” of the Ministry of Health of the Russian Federation15072019222-28318331606202016062020Copyright © 2019, Kudrevich Y.V., Kuznetsova E.K., Ziganshin O.R., Sychugov G.V., Zayats T.A., Emelina A.I.2019<p>The study involved healthy women, the average age of whom was 45.0±3.41. All patients received a single procedure for the biorevitalization of the facial skin. Some indicators of systemic and tissue immunity were evaluated. When analyzing the number of immune cells in the skin before and after the procedure, the amount of CD3<sup>+</sup>, CD4<sup>+</sup>, CD8<sup>+</sup> was doubled. The amount of CD20+ remained practically unchanged. When assessing immunoglobulins M, G in the skin before and after the procedure, a decrease in these indicators was observed. IgA practically did not change. The amount of immunoglobulins in the skin changed as well as in the blood. It decreased. When assessing the parameters of cellular immunity of blood, it was found out that the cellular composition of the blood does not practically change. Significant changes occurred only in the absolute and relative amount of CD3<sup>–</sup>CD56<sup>+</sup>. These indicators signifi cantly increased. </p>biorevitalizationsystemic immunitycellular immunity of the skinskin immunoglobulinsбиоревитализациясистемный иммунитетклеточный иммунитет кожииммуноглобулины кожи[1. Deglesne P. A., Arroyo R., Ranneva E., Deprez P. In vitro study of RRS HA injectable mesotherapy /biorevitalization product on human skin fibroblasts and its clinical utilization // Clin Cosmet Investig Dermatol. 2016 Feb 23;9:41–53.][2. El-Domyati M., El-Ammavi T. S., Moawad O., El-Fakahany H., Medhat W., Mahoney M. G., Uitto J. Efficacy of mesotherapy in facial rejuvenation: a histological and immunohistochemical evaluation // Int J Dermatol. –2012. – Aug; 51(8):913–9.][3. Savoia A., Landis S., Baldi A. A new minimally invasive mesotherapy technique for facial rejuvenation // Dermatol Ther (Heidelb). –2013. – Jan 8;3(1):83–93.][4. Гизингер О. А., Шишкова Ю. С., Липская А. Д., Зиганшин О. Р., Черновол П. Ю., Кудревич Ю. В., Летяева О. И. Клинико-микробиологические особенности состояния кожи лица у женщин до и после процедуры инвазивной биоревитализации // Южно-Ураль ский медицинский журнал. – 2015. – № 3. – С. 33–36.][5. Кудревич Ю. В., Сычугов Г. В., Зиганшин О. Р., Заяц Т. А. Изменения структурных показателей кожи при воздействии биоревитализации // Уральский медицинский журнал. – 2016. – № 3 (136). – С. 117– 121.]