Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology41510.31857/S102872210006532-0INTERNET DEPENDENCE IN ADOLESCENTS OF CENTRAL SIBERIATereshchenkoS. Y.<p>DM, Professor, Head of the Clinical Department of Somatic and Mental Health of Children, </p><p>Krasnoyarsk</p>smarinv@yandex.ruSmolnikovaM. V.<p>PhD, Leading researcher,</p><p>Krasnoyarsk</p>smarinv@yandex.ruScientific Research Institute of Medical Problems of the North FRC KSC SB RAS15072019222-29489502407202024072020Copyright © 2019, Tereshchenko S.Y., Smolnikova M.V.2019Pathological Internet addiction belongs to the group of multifactorial polygenic diseases, where in each case there is a unique combined effect of the innate features of the functioning of higher nervous activity, some of which are genetically determined with the influence of many environmental factors. In this regard, one of the most important fundamental tasks is the identifi cation of specific genes and neurotransmitter associations responsible for the propensity to form Internet addiction in adolescents, which will lead to a search for new therapeutic targets and ways of early prevention with an assessment of the degree of genetic risk.Internet addictionadolescentsgenetic determinismинтернет-зависимостьподросткигенетическая детерминированность[1. Han D. H., Lee Y. S., Yang K. C., Kim E. Y., Lyoo I. K., Renshaw P. F. Dopamine genes and reward dependence in adolescents with excessive internet video game play. J Addict Med, 2007, 1(3), 133–138.][2. Jeong J. E., Rhee J. K., Kim T. M., Kwak S. M., Bang S. H., Cho H., Cheon Y. H., Min J. A., Yoo G. S., Kim K., Choi J. S., Choi S. W., Kim D. J. The association between the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults. PLoS ONE, 2017, 12(12), e0188358.][3. Montag C., Kirsch P., Sauer C., Markett S., Reuter M. The role of the CHRNA4 gene in Internet addiction: a case-control study. J Addict Med, 2012, 6(3), 191–195.][4. Малыгин В. Л., Меркурьева Ю. А., Искандирова А. Б., Пахтусова Е. Е., Прокофьева А. В. Особенности ценностных ориентаций у подростков с интернет-зависимым поведением. Медицинская психология в России, 2015, 33(4),1–20.][5. Chen S.-H., Weng L.- J., Su Y.-J., Wu H.-M., Yang P.-F. Development of a Chinese Internet Addiction Scale and Its Psychometric Study. Chinese Journal of Psychology, 2003, 45(3), 279–294.]