Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology598PECULIARITIES OF IMMUNE REGULATION IN CHILDREN UNDER INDUSTRIAL EXPOSURE TO METALSDolgikhO. V.noemail@neicon.ruStarkovaK. G.noemail@neicon.ruOtavinaE. A.noemail@neicon.ruKazakovaO. A.noemail@neicon.ruGuselnikovM. A.noemail@neicon.ruZhdanovaI. G.noemail@neicon.ruFBUN "Federal scientific center of medico-preventive technologies of risk management to health of the population1504201720212012222102020Copyright © 2017, Dolgikh O.V., Starkova K.G., Otavina E.A., Kazakova O.A., Guselnikov M.A., Zhdanova I.G.2017Changes of immune parameters in children under conditions of industrial metals contamination were associated with a decrease in phagocytic activity, inhibition of CD4 and CD95 expression and an augmentation in the number of CD25<sup>+</sup> and CD127<sup>-</sup> lymphocytes, an increase in IgE content of total and specific IgG to aluminum, activation of synthesis of non-specific mediators of leukotrienes C4/D4/E4.лейкотриеныCD-маркерыметаллыleykotriyensCD markersmetals[Cмагулов Н. К. Ажиметова Г. Н. Международный журнал экспериментального образования. 2013, 11, 57-60.][Duramad P., Holland N. T. Int. J. Environ. Res. Public Health. 2011, 8 (5), 1388-1401.][Долгих О. В., Кривцов А. В., Бубнова О. А., Отавина Е. А., Безрученко Н. В. и др. Гигиена и санитария. 2017, 96(1), 26-29.][Lehmann I., Sack U., Lehmann J. Met. Ions Life Sci. 2011,8,157-185.]