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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Immunology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Immunology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский иммунологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1028-7221</issn><issn publication-format="electronic">2782-7291</issn><publisher><publisher-name xml:lang="en">Russian Society of Immunology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">598</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">PECULIARITIES OF IMMUNE REGULATION IN CHILDREN UNDER INDUSTRIAL EXPOSURE TO METALS</article-title><trans-title-group xml:lang="ru"><trans-title>ОСОБЕННОСТИ ИММУННОЙ РЕГУЛЯЦИИ У ДЕТСКОГО НАСЕЛЕНИЯ В УСЛОВИЯХ ЭКСПОЗИЦИИ МЕТАЛЛАМИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dolgikh</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Долгих</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Starkova</surname><given-names>K. G.</given-names></name><name xml:lang="ru"><surname>Старкова</surname><given-names>К. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Otavina</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Отавина</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kazakova</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Казакова</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Guselnikov</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Гусельников</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhdanova</surname><given-names>I. G.</given-names></name><name xml:lang="ru"><surname>Жданова</surname><given-names>И. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">FBUN "Federal scientific center of medico-preventive technologies of risk management to health of the population</institution></aff><aff><institution xml:lang="ru">ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2017</year></pub-date><volume>20</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>120</fpage><lpage>122</lpage><history><date date-type="received" iso-8601-date="2020-10-22"><day>22</day><month>10</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Dolgikh O.V., Starkova K.G., Otavina E.A., Kazakova O.A., Guselnikov M.A., Zhdanova I.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Долгих О.В., Старкова К.Г., Отавина Е.А., Казакова О.А., Гусельников М.А., Жданова И.Г.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Dolgikh O.V., Starkova K.G., Otavina E.A., Kazakova O.A., Guselnikov M.A., Zhdanova I.G.</copyright-holder><copyright-holder xml:lang="ru">Долгих О.В., Старкова К.Г., Отавина Е.А., Казакова О.А., Гусельников М.А., Жданова И.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rusimmun.ru/jour/article/view/598">https://rusimmun.ru/jour/article/view/598</self-uri><abstract xml:lang="en"><p>Changes of immune parameters in children under conditions of industrial metals contamination were associated with a decrease in phagocytic activity, inhibition of CD4 and CD95 expression and an augmentation in the number of CD25<sup>+</sup> and CD127<sup>-</sup> lymphocytes, an increase in IgE content of total and specific IgG to aluminum, activation of synthesis of non-specific mediators of leukotrienes C4/D4/E4.</p></abstract><trans-abstract xml:lang="ru"><p>Выявлены изменения иммунных показателей у детей в условиях промышленного загрязнения металлами, связанные со снижением фагоцитарной активности, угнетением экспрессии CD4 и CD95 и повышением количества CD25<sup>+</sup>- и CD127<sup>-</sup>-лимфоцитов, увеличением содержания IgE общего и специфического IgG к алюминию, активацией синтеза неспецифических медиаторов лейкотриенов C4/D4/E4.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лейкотриены</kwd><kwd>CD-маркеры</kwd><kwd>металлы</kwd><kwd>leykotriyens</kwd><kwd>CD markers</kwd><kwd>metals</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Cмагулов Н. 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