Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology654ALLERGIC DISEASES AND <i>HELICOBACTER PYLORI </i>INFECTION PART 2. sIgE MUCOSAL IMMUNE RESPONSE TO <i>H. PYLORI</i>GervazievaV. B.noemail@neicon.ruMazurinaS. A.noemail@neicon.ruIlintsevaN. V.noemail@neicon.ruSveranovskayaV. V.noemail@neicon.ruI. Mechnikov Research Institute of Vaccines & Sera1504201720227828022102020Copyright © 2017, Gervazieva V.B., Mazurina S.A., Ilintseva N.V., Sveranovskaya V.V.2017The levels of sIgA, CagA, IL-17, sIgE-to H.pylori and to CagA have been analyzed by ELISA in the samples of coprofiltrates, taken from children with allergy and concomitant gastrointestinal diseases. Anti-H. pylori and anti-CagA sIgE have been elevated in groups of patients with allergic diseases in combination with chronic gastroduodenitis and among children with erosive and ulcerous leisons, being the most significant among the last group. Non-allergic patients with chronic gastroduodenitis were characterized by the highest concentration of IL-17 and sIgA, which was associated with the confirmed H.pylori infection. Our data demonstrates that sIgE to H.pylori, together with sIgA, represent a part of protective mechanisms during the H.pylori -assosiated gastrointestinal pathology.аллергияхронический гастродуоденитsIgE к H.pylori и CagAallergychronic gastroduodenitis[Liu A. H. Revisiting the hygiene hypothesis for allergy and asthma. J. Allergy Clin. Immunol. 2015; 136 (4), 860-865.][Rad R., Brenner L., Bauer S., et al. СD25+/Foxp3+ T cells regulate gastric infl ammation and Helicobacter pylori colonization in vivo. Gastroenterology. 2006;131(2):525-37.][Lee S. P., Lee S. Y., Kim J. H., et al. Correlation between Helicobacter pylori infection, IgE hypersensitivity, and allergic disease in Korean adults. Helicobacter. 2015; 20(1): 49-55.][Hussain K., Letley D. P., Greenaway A. B., Winter J. A. et al. Helicobacter pylori-mediated protection from allergy is associated with Il-10-secreting peripheral blood regulatory T cells. Front. Immunol. 2016; 7: 71-86.][Magen E., Schlesinger M., David M., Ben-Zion I., Vardy D. Selective IgE defi ciency, immune dysregulation, and autoimmunity. Allergy Asthma Proc 2014; 35: e27-e33]