Russian Journal of ImmunologyRussian Journal of ImmunologyРоссийский иммунологический журнал1028-72212782-7291Russian Society of Immunology657ArticlesСтатьиTHE REGULATION OF TREG DIFFERENTIATION BY ENDOGENOUS MELATONIN DURING PREGNANCYРЕГУЛЯЦИЯ ДИФФЕРЕНЦИРОВКИ TREG ЭНДОГЕННЫМ МЕЛАТОНИНОМ ПРИ БЕРЕМЕННОСТИGlebezdinaN. S.ГлебездинаН. С.
Russian Federation
OlinaA. A.ОлинаА. А.
Russian Federation
NekrasovaI. V.НекрасоваИ. В.
Russian Federation
KuklinaE. M.КуклинаЕ. М.
Russian Federation
Institute of Ecology and Genetics of Microorganisms, UB RASИнститут экологии и генетики микроорганизмов УрО РАНPerm State Medical University named after academician E. A. Wagner of the Ministry of healthcare of the Russian FederationФГБОУ ВО ПГМУ им. академика Е. А. Вагнера Минздрава России1504201720228528622102020Copyright ©; 2017, Glebezdina N.S., Olina A.A., Nekrasova I.V., Kuklina E.M.Copyright ©; 2017, Глебездина Н.С., Олина А.А., Некрасова И.В., Куклина Е.М.2017Glebezdina N.S., Olina A.A., Nekrasova I.V., Kuklina E.M.Глебездина Н.С., Олина А.А., Некрасова И.В., Куклина Е.М.https://creativecommons.org/licenses/by/4.0https://rusimmun.ru/jour/article/view/657

The role of endogenous melatonin in the regulation of the process of regulatory T cells (Treg) differentiation during the gestation period has been studied. The difference in the regulation of this process by the hormone was shown in non-pregnant and pregnant women. The positive effect of melatonin on the cells in vitro mediated by signals from membrane receptors for the hormone in response to polyclonal activation was revealed at pregnancy.

Исследована роль эндогенного мелатонина в регуляции процесса дифференцировки регуляторных Т-клеток (Treg) в период гестации. Показано различие в регуляции данного процесса гормоном у небеременных и беременных женщин. При беременности выявлено позитивное действие мелатонина на клетки in vitro, опосредованное сигналами с мембранных рецепторов для гормона, в ответ на поликлональную активацию.

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