Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology682STUDY OF THE BIOLOGICAL AND MECHANICAL PROPERTIES OF THE ULTRA-HIGH-MOLECULAR-WEIGHT-POLY-ETHYLENE COMPOSITE FOR EMPLOYMENT AS CARTILAGE BIOIMPLANTKiselevskyM. V.noemail@neicon.ruAnisimovaN. Yu.noemail@neicon.ruLebedinskayaO. V.noemail@neicon.ruKopylovA. N.noemail@neicon.ruNN Blokhin Scientifi c Institutе “Russian Cancer Research Center”Acad. EA Wagner Perm State Medical University1504201720234735022102020Copyright © 2017, Kiselevsky M.V., Anisimova N.Y., Lebedinskaya O.V., Kopylov A.N.2017Aim of this study is researching the biological and mechanical features of the material, made of ultra-high-molecular-weight-poly-ethylene(UHMWPE) Studing the mechanical features showed that the material prepared with addition of Al<sub>2</sub>O<sub>3</sub> and with using mechanical activation has the highest mechanical features, wear resistance in particular, in comparison with UHMWPE samples without Al<sub>2</sub>O<sub>3</sub> or prepared without mechanical activation. was chosen for. After 60 days orthotopical transplantation this material in rats we did not fined signs of inflammation, cellular infiltration, destruction of material or bone-cartilage defect. Sample was in position of implantation without any shifts. Acquired data shows the perspective-ness of UHMWPE as a material for creating bioimplants for cartilage defects replacement.сверхвысокомолекулярный полиэтилен (СВМПЭ)хрящрепарацияимплантатultra-high-molecular-weight-poly-ethylene (UHMWPE)cartilagereparationimplant[Bobic V. Articular cartilage - to repair or not to repair / Bobic V., Noble J. // British Editorial Society of Bone and Joint Surgery J Bone Joint Surg [Br].-2000-82 - P. 165-166.][Perera J. The present state of treatments for articular cartilage defects in the knee / Perera J., Gikas P., Bentley G. // Annals of The Royal College of Surgeons of England.- 2012-94.- P. 381-387.][Curl W. Cartilage injuries: a review of 31,516 knee arthroscopies / Curl W., Krome J., Gordon E. // Arthroscopy.- 1997-13 - P. 456-460.][Simon C. Functional articular cartilage repair: here, near, or is the best approach not yet clear? / Simon C., Daniёl B., Saris and Floris P. // Journal Nature Reviews Rheumatology- 2013-9 - P. 277-290.][Redman S. Current strategies for articular cartilage repair / Redman S., Oldfield S. and Archer C. // Eur. Cell Mater.- 2005.- 9 - P. 23-32.][Repair of defects in articular joints / Lynn A., Brooks R., Bonfield W., Rushton N. // J Bone Joint Surg Br.- 2004-86 - P. 1093-1099.][UHMWPE biomaterials handbook Steven M. Kurz - 2009.][Исследование биосовместимости и иммуногенности синтетических имплантатов / Копылов А. Н., Лебединская О. В., Анисимова Н. Ю., Сенатов Ф. С., Максимкин А. В., Киселевский М. В. // Российский иммунологический журнал.-2013.- Т. 7.- № 2-3.- С. 304-305.]