Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology755INTRASPECIFIC AND INTERSPECIFIC PATTERNS OF MICROBIOTA - INFLAMMATORY HOST POTENTIAL INTERACTIONS IN CHILDREN WITH ASDTimofeevaA. V.noemail@neicon.ruFilippovaYu. Yu.noemail@neicon.ruPolyakovaE. A.noemail@neicon.ruBurmistrovaA. L.noemail@neicon.ruChelyabinsk State University1507201720352953122102020Copyright © 2017, Timofeeva A.V., Filippova Y.Y., Polyakova E.A., Burmistrova A.L.2017Analysis of correlation links of intraspecies patterns - “microbe - microbe”, “microbe - endotoxin”, inflammatory potential of the host “cytokine - cytokine” and interspecies - “microbe - host” demonstrates close relationships between members of the small intestine microbiota community in healthy children and in children with ASD. Statistically significant correlations of the pattern of the inflammatory potential of the cytokine-cytokine host and of the pattern of interspecies links “microbe - host” were registered only in the group of children with ASD.микробиота тонкого кишечникапровоспалительные цитокинырасстройства аутистического спектра (РАС)small intestine microbiotaproinflammatory cytokinesautism spectrum disorders (ASD)[Wang L., Conlon M. A., Christophersen C. T., Sorich M. J., Andley M. T., Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders. Biomark Med 2014, 8 (3), 331-344.][Cryan J. F., Dinan T. G. Mind-altering microorganisms: the impact of the gut microbiota on brain and behavior. Nat. Rev. Neurosci. 2013, 13(10), 701-712.][Hsiao E. Y., McBride S.W., Hsien S., Sharon G., Hyde E. R., et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013, 155 (7), 1451-1463.][Bradley J. Ferguson, Sarah Marler, Lily L. Altstein, Evon Batey Lee, Micah O. Mazurek, et all. Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder. Brain Behav. Immun. 2016, 58, 57-62.]