Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology86910.31857/S102872210002385-8Antipeptide activity of intestinal microsyмbyonts for the state of intestinal homeostasis estimationBondarenkoT. .noemail@neicon.ruDanilovaE. .noemail@neicon.ruChainikovaI. .noemail@neicon.ruChelpachenkoO. .noemail@neicon.ruIvanovaE. .noemail@neicon.ruPerunovaN. .noemail@neicon.ruNikiforovI. .noemail@neicon.ruInstitute for Cellular and Intracellular Symbiosis of Ural Branch of RASOrenburg State Medical University1507201821322222622102020Copyright © 2018, Bondarenko T..., Danilova E..., Chainikova I..., Chelpachenko O..., Ivanova E..., Perunova N..., Nikiforov I...2018<p>The paper presents the results of antipeptide activity against pro (TNF, IFN-, IL-6, IL-17) and anti-infl ammatory (IL-10) cytokines of exometabolites of the intestinal microfl ora, isolated in patients with eubiosis, dysbiosis of the large intestine and reactive arthritis. Diff erences in strains of normofl ora and opportunistic microorganisms isolated from various sources, the spectrum of cytokines and the level of their decrease their content in the culture medium were determined upon co-cultivation with exometabolites of the cultures of microorganisms under study. The results obtained can be used to assess the immunoregulatory properties of microfl ora in various microecological conditions of the human colon and in extraintestinal infl ammatory pathology.</p>intestinal microsymbiontscytokinesdysbiosisreactive arthritisкишечные микросимбионтыцитокиныдисбиозреактивный артрит[Peterson C. T., Sharma V., Elmén L., Peterson S. N. Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota. Clinical and Experimental Immunology 2015, 179(3), 363–377.][Gonçalves P., Araújo J. R., Di Santo J. P. A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Infl ammatory Bowel Disease. Infl amm. Bowel Dis. 2018, 24(3), 558–572][Asquith M., Elewaut D., Lin P., Rosenbaum J. T. The role of gut and microbes in the pathogenesis of spondyloarthritis. Best Pract Res Clin Rheumatol. 2014, 28(5), 687–702.][Симбирцев А. С. Цитокины в патогенезе и лечении заболеваний человека. Фолиант, СПб, 2018, 512 с.][Hoeppli R. E., Wu D., Cook L., Levings M. K. The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome. Front Immunol. 2015, 6: 61. doi: 10.3389/fi mmu.2015.00061.][Wilson M., Seymour R., Henderson B. Bacterial perturbation of Cytokine Networks. Infect. Immun. 1998, 66 (6), 2401–2409.][Potempa J., Pike R. N. Corruption of Innate Immunity by Bacterial Proteases. J. Innate Immun. 2009, 1 (2): 70–87][Бухарин О.В., Перунова Н. Б., Чайникова И. Н., Иванова Е. В., Смолягин А. И. Антицитокиновая активность микроорганизмов. Журн. микробиол. 2011, 4, 56–61.][Ma N., Guo P., Zhang J., He T., Kim S. W., Zhang G., Ma X. Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk. Frontiers in Immunology, 2018, 9, 5. http://doi.org/10.3389/fi mmu.2018.00005]