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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Immunology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Immunology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский иммунологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1028-7221</issn><issn publication-format="electronic">2782-7291</issn><publisher><publisher-name xml:lang="en">Russian Society of Immunology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">882</article-id><article-id pub-id-type="doi">10.31857/S102872210002398-2</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Experimental justification of the possibility of creating the new metabolic drug</article-title><trans-title-group xml:lang="ru"><trans-title>Экспериментальное обоснование возможности создания нового метаболического препарата</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zabokritsky</surname><given-names>N. .</given-names></name><name xml:lang="ru"><surname>Забокрицкий</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sarapultsev</surname><given-names>P. .</given-names></name><name xml:lang="ru"><surname>Сарапульцев</surname><given-names>П. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal State Budgetary Scientifi c Institution Research Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Институт иммунологии и физиологии Уральского отделения Российской академии наук</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2018</year></pub-date><volume>21</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>295</fpage><lpage>300</lpage><history><date date-type="received" iso-8601-date="2020-10-22"><day>22</day><month>10</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Zabokritsky N..., Sarapultsev P...</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Забокрицкий Н.А., Сарапульцев П.А.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Zabokritsky N..., Sarapultsev P...</copyright-holder><copyright-holder xml:lang="ru">Забокрицкий Н.А., Сарапульцев П.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rusimmun.ru/jour/article/view/882">https://rusimmun.ru/jour/article/view/882</self-uri><abstract xml:lang="en"><p>This scientifi c work is devoted to the study of the possibility of creating a new metabolic drug (using biologically active substances of the probiotic strain Bacillus subtilis B-3679) for use as a preventive and therapeutic agent for infl ammatory diseases of tissues and organs of the oral cavity. Previously, the metabolites of spore probiotic microorganisms were practically not used for the design of medical pharmacological preparations.</p></abstract><trans-abstract xml:lang="ru"><p>В работе приведены результаты исследования, посвященные изучению возможности создания нового метаболического препарата (с использованием биологически активных веществ пробиотического штамма Bacillus subtilis B-3679) для применения в качестве профилактического и лечебного средства при воспалительных заболеваниях тканей и органов ротовой полости. Ранее метаболиты споровых пробиотических микроорганизмов практически не использовались для конструирования медицинских фармакологических препаратов.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>probiotic microorganisms</kwd><kwd>metabiotic</kwd><kwd>experimental study</kwd><kwd>пробиотические микроорганизмы</kwd><kwd>метабиотик</kwd><kwd>экспериментальное обоснование</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Забокрицкий Н. А. Экспериментальная оценка коррекции гуморального иммунитета гепатопротекторным препаратом гепатобиол у лабораторных животных с острым токсическим гепатитом. Российский иммунологический журнал, 2017, 11, 2(20), 123–126. [Zabokritskiy N. A. Experimental estimation of correction of humoral immunity hepatoprotective drug hepatobiol in laboratory animals C acute toxic hepatitis, 2017, 11, 2(20), 123–126].</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Забокрицкий Н. А. 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