Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology89110.31857/S102872210002407-2Study of migration of nano-dimensional metallic particles in the composition of supernatants on the model of inbreed mobiles BALB-CJLabisV. .noemail@neicon.ruBazikyanE. .noemail@neicon.ruManskihV. .noemail@neicon.ruSizovaS. .noemail@neicon.ruKhaidukovS. .noemail@neicon.ruKozlovI. .noemail@neicon.ruMoscow State University of Medicine and Dentistry named after A.I. EvdokimovThe Institute of Mitoengineering of Lomonosov Moscow State UniversityInstitute of Bioorganic Chemistry named by Academicians M.M. Shemyakin and Y.A. OvchinnikovFNKTS children’s hematology, oncology and immunology D. Rogachev1507201821334234722102020Copyright © 2018, Labis V..., Bazikyan E..., Manskih V..., Sizova S..., Khaidukov S..., Kozlov I...2018<p>The purpose of this study was to investigate the ability of migration into the immunocompetent organs of nanoscale metal particles in the composition of supernatants. The goal is to model peritonitis, with intraperitoneal administration of solutions, in particular, with induction and without induction by lipopolysaccharide. Nanoscale metal particles were obtained in the laboratory from the surface of the dental implants “Nobel Biocare” and “Alpha BiO” in the composition of supernatants. In the experiment, 12 inbred mice, divided conditionally into 3 groups were injected with solutions: antibiotic, nanoscale particles obtained from two systems of dental implants in supernatants. On day 10 three organs were examined: the liver, kidney and spleen. A histological study indicated the presence of Al2O3, nanoparticles, found on the boundary between white and red pulp inside macrophages in the group injected with supernatants taken from Alpha BIO surface.</p>nanoscale metal particlesmouse modelaseptic peritonitisspleenнаноразмерные металлические частицымышиная модельасептический перитонитселезенка[Lafaurie G. I., Sabogal M. A., Castillo D. M., Rincón M. V., Gómez L. A., Lesmes Y. A., Chambrone L. Microbiome and Microbial Biofi lm Profi les of Peri-Implantitis: A Systematic Review // J Periodontol. 2017. 19: 1–26. doi: 10.1902/jop.2017.170123.][Shah R., Penmetsa D. S.L., Thomas R., Mehta D. S. Titanium Corrosion: Implications For Dental Implants // Eur J Prosthodont Restor Dent. 2016. 24(4): 171–180. doi: 10.1922/EJPRD_1531Shah10.][Лабис В. В., Базикян Э. А., Козлов И. Г., Сизова С. В., Хайдуков С. В. Наноразмерные частицы – участники остеоинтеграции // Бюллетень Оренбургского научного центра УрО РАН. 2016. 1: 1–18. [Labis V. V. Bazikyan E. A., Kozlov I. G., Sizova S. V., Hajdukov S. V. Nanosized particles – participants of osseointrgration. Bulletin of Orenburg scientifi c center of UrB RAS, 2016. 1: 1–18. (URL: http://elmag.uran.ru:9673/magazine/Numbers/2016–1/Articles/LVV-2016–1.pdf)]][Лабис В. В., Базикян Э. А., Сизова С. В., Хайдуков С. В., Козлов И. Г. Исследование наноразмерных частиц, полученных в супернатантах с дентальных имплантатов двух систем А и В // Бюллетень Оренбургского научного центра УрО РАН. 2016. 2: 16с. [Labis V. V. Bazikyan E. A., Sizova S. V., Hajdukov S. V., Kozlov I. G. Nanosized particles obtained in supernatanes from dental implants of systems A and B // Bulletin of Orenburg scientifi c center of UrB RAS, 2016. 1: 1–18. (URL: http://elmag.uran.ru:9673/magazine/Numbers/2016–2/Articles/VVL-2016–2.pdf)]/]