Russian Journal of ImmunologyRussian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology90010.31857/S102872210002416-2ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИSubpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritisСубпопуляции Т-лимфоцитов у детей с различной активностью ювенильного идиопатического артритаPashninaI. .ПашнинаИ. А.
Russian Federation
Regional Children’s Clinical Hospital № 1Областная детская клиническая больницаInstitute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.Институт иммунологии и физиологии РАН1507201821339139522102020Copyright ©; 2018, Pashnina I...Copyright ©; 2018, Пашнина И.А.2018Pashnina I...Пашнина И.А.https://creativecommons.org/licenses/by/4.0https://rusimmun.ru/jour/article/view/900

Children of 6–17 years old with diff erent activity of juvenile idiopathic arthritis were examined: 74 with active arthritis and 14 with remission were treated with disease modifying therapy, 12 children with persistent remission and 32 apparently healthy children were without medications. The amount of CD3+, CD3+CD4+, CD3+CD8+, СD3+СD4–СD8–, СD3+СD4+СD8+, СD3+СD16/56+, СD3+СD4+СD25+СD127low/neg and СD3+СD4+СD25+СD127+ were investigated by fl ow cytometry. In all children with juvenile idiopathic arthritis the number regulatory T-cells (CD3+CD4+CD25+CD127low/neg) and double-positive lymphocytes (СD3+СD4+СD8+) was decreased. The amount of NKT (СD3+СD16/56+) in patients with active arthritis and with remission was too decreased.

Обследованы дети 6–17 лет с ювенильным идиопатическим артритом (ЮИА): 74 больных в стадии активности заболевания и 14 пациентов c ремиссией получали болезнь-модифицирующую терапию, 12 детей со стойкой ремиссией и 32 здоровых ребенка (контроль) не получали лечение. Методом проточной цитометрии исследовано количество CD3+, CD3+CD4+, CD3+CD8+, СD3+СD4– СD8–, СD3+СD4+СD8+, СD3+СD16/56+, СD3+СD4+СD25+СD127low/neg и СD3+СD4+СD25+СD127+ в периферической крови. У всех пациентов с ЮИА было снижено количество регуляторных Т-клеток (СD3+СD4+СD25+СD127low/neg) и дубль-позитивных Т-клеток (СD3+СD4+СD8+) по сравнению с контролем. У больных с активной стадией ЮИА и медикаментозной ремиссией также наблюдалось снижение количества Т-натуральных киллеров (СD3+СD16/56+).

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