Russian Journal of ImmunologyRussian Journal of Immunology1028-72212782-7291Russian Society of Immunology91510.31857/S102872210002431-9Spermatogenesis and mast cells of the testes with damage and against the background of the introduction of glucocorticosteroidsKhramtsovaYu. .noemail@neicon.ruTуumentsevaN. .noemail@neicon.ruArtashyanO. .noemail@neicon.ruBukharinaA. .noemail@neicon.ruInstitute of Immunology and Physiology, Ural Branch of Russian Academy of SciencesUral Federal University named after the first President of Russia B.N. Yeltsin1507201821347948522102020Copyright © 2018, Khramtsova Y..., Tуumentseva N..., Artashyan O..., Bukharina A...2018<p>The immune system plays an important role in the regulation of restorative processes in various tissues and organs, including immunoprivileged ones, which include the testes. Mast cells (TK) are one of the elements of the microenvironment of the testis and take part in maintaining testicular homeostasis. With various traumas of testes, therapy with corticosteroids with anti-infl ammatory and immunosuppressive properties is indicated. The role of TC in the process of recovery of spermatogenesis with the administration of corticosteroids remains unknown, which was the purpose of this study. It was found that after damage to the hemato-testicular barrier of rats, against the background of the introduction of prednisolone, there is an increase in the synthetic activity of TC, with an invariable in the number and the level of degranulation. This phenomenon is refl ected positively on the process of recovery of spermatogenesis, the development of destructive processes is weakened, as there is a tendency to increase the number of spermatogonia and decrease the number of nonfunctioning tubules.</p>spermatogenesismast cellstestescorticosteroidsсперматогенезтучные клеткисеменникикортикостероиды[Божедомов В. А., Лоран О. Б., Сухих Г. Т. Этиология и патогенез мужского аутоиммунного бесплодия. Андрология и генитальная хирургия 2001, 1, 72–77. [Bozhedomov V. A., Laurent O. B., Sukhikh G. T. Etiology and pathogenesis of male autoimmune infertility. Andrology and genital surgery 2001, 1, 72–77].][Meinhardt A., Hedger M. P. Immunological, paracrine and endocrine aspects of testicular immune privilege. Mol. Cell. Endocrinol 2011, 335 (1), 60–68.][Zhao S., Zhu W., Xue S., Han D. Testicular defense systems: immune privilege and innate immunity. Cell Mol. Immunol. 2014, 11 (5), 428–437.][Юшков Б. Г., Черешнев В. А., Климин В. Г., Арташян О. С. Тучные клетки. Физиология и патофизиология. Медицина, Москва 2011, 237 с. [Yushkov B. G., Chereshnev V. A., Klimin V. G., Artashyan O. S. Mast cells. Physiology and pathophysiology. Medicine, Moscow 2011, 237р.].][Jacobo P. V., Fass M., Perez C. V., Jarazo-Dietrich S., Lustig L., Theas M. S. Involvement of soluble Fas Ligand in germ cell apoptosis in testis of rats undergoing autoimmune orchitis. Cytokine 2012, 60 (2), 385–92.][Windschuttl S., Nettersheim D., Schlatt S., Huber A., Welter H., Schwarzer J. U., Kohn F. M., Schorle H., Mayerhofer A. Are testicular mast cells involved in the regulation of germ cells in man? Andrology 2014, 2 (40), 615–622.][Страчунский Л. С., Козлов С. Н. Глюкокортикоидные препараты: методическое пособие. Смоленск: Смоленская государственная медицинская академия, 30 с. [Strachunsky L. S., Kozlov S. N. Glucocorticoid preparations: methodical allowance. Smolensk, 30 р.].][Внуков П. В. Новый способ оценки атрофических изменений яичка. Научно-медицинский вестник Центрального Черноземья 2007, 27, 32–37. [Vnukov P. V. A new estimation method of the atrophic changes in the testicle. Scientifi c Medical Journal of the Central Chernozemye 2007, 27, 32–37.].][Astaldi G., Verga Z. The glycogen content of the cells of lymphatic leukemia. Haemat. 1957, 17, 129–131.][Саяпина И. Ю. Репродуктивная функция семенников крыс после семидневной адаптации к низким температурам по данным морфологического анализа. Научный журнал КубГАУ 2013, 89 (05), 329–341. [Sayapina I. Yu. Reproductive function of the rat testis after 7-day adaptation to low temperatures, according to the morphological analysis. Scientifi c Journal KubSAU2013, 89 (05), 329–341.].]