ABOUT THE NAKED MOLE RAT LYMPHOID TISSUES

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Abstract

The naked mole-rat (Heterocephalus glaber) is an eusocial rodent living underground, known for its unusually high life expectancy. Biochemical markers of age associated diseases (cancer, neurodegenerative diseases) in naked mole-rat are less pronounced than in other laboratory rodents. The immune system is involved in the aging and carcinogenesis regulation, however, the immune system in the naked mole-rats is yet not investigated well. We found that the immune system of naked mole-rats has structural diff erences compared to a mouse immune system: a smaller number of the bone marrow cells and splenocytes, the small size of the lymphoid follicles of the spleen and lymph nodes, a higher proportion of myeloid cells in the periphery. Taken together, these data provide a basis for studying the fundamental immunity patterns of the naked mole rat, and their contribution to the extraordinary longevity.

About the authors

E. A. Gorshkova

Lomonosov Moscow State University;
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences;
Belozersky Institute of PhysicoChemical Biology, Lomonosov Moscow State University

Author for correspondence.
Email: gorshsama@gmail.com

PhD student, Department of Immunology, Biological Faculty,

Moscow

Russian Federation

E. O. Gubernatorova

Lomonosov Moscow State University;
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: fake@neicon.ru

PhD student, Department of Immunology, Biological Faculty, 

Moscow

Russian Federation

A. D. Medvedovskaya

Lomonosov Moscow State University

Email: fake@neicon.ru

student, Department of Immunology, Biological Faculty, 

Moscow

Russian Federation

M. Yu. Vyssokikh

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

Email: fake@neicon.ru

PhD (Biology), head of laboratory, 

Moscow

Russian Federation

S. Holtze

Leibniz-Institute for Zoo and Wildlife Research

Email: fake@neicon.ru

scientist, Department of Reproduction Management, 

Berlin

Germany

T. B. Hildebrandt

Leibniz-Institute for Zoo and Wildlife Research

Email: fake@neicon.ru

Professor, head of Reproduction Management Department, 

Berlin

Germany

M. S. Drutskaya

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: fake@neicon.ru

PhD (Biology), leading researcher, 

Moscow

Russian Federation

S. A. Nedospasov

Lomonosov Moscow State University;
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences;
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

Email: sergei.nedospasov@gmail.com

MD (Biology), Professor, academician, head of Department of Immunology, Biological Faculty;

head of laboratory;

head of laboratory, 

119334, Moscow, Vavilova srt., 32.

Russian Federation

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Copyright (c) 2019 Gorshkova E.A., Gubernatorova E.O., Medvedovskaya A.D., Vyssokikh M.Y., Holtze S., Hildebrandt T.B., Drutskaya M.S., Nedospasov S.A.

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