ASSOCIATIONS OF THE SPECIFIC IMMUNE REACTIONS ON THE CHEMICAL CARCINOGENS AND STEROID HORMONES WITH THE GENE POLYMORPHISMS OF DNA-REPAIR ENZYMES IN BREAST CANCER PATIENTS



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Abstract

The supposed interrelations of antibodies specific to low-weight xeno- and endobiotics with DNA-repair genes polymorphisms were studied in postmenopausal healthy women (HW) and breast cancer patients (BCP). Enzyme-linked immunoassay was used for IgA and IgG to benzo[a]pyrene, estradiol and progesterone detection in 215 HW and 344 BCP. Gene polymorphisms of XPD/ERCC2 (rs13181), ADPRT/PARP1 (rs1136410), HOGG1 (rs1052133), XRCC1 (rs25489) were analyzed by allele-specific PCR. No associations of studied gene polymorphisms with breast cancer were revealed, as well as interrelations between immunological and genetic parameters in HW. It was detected that levels of IgG specific to benzo[a]pyrene, estradiol and progesterone were associated with the C allele of ADPRT/PARP1 (p=0.02; p=0.003; p=0.006 accordingly). Therefore, it was confirmed that genes of DNA-repair enzymes could determine formation of antibodies specific to the chemical carcinogens and endogenous steroids.

About the authors

E. G. Polenok

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

PhD (Candidate of Pharmacy), Leading Researcher of Immunochemistry Laboratory,

Kemerovo

Russian Federation

V. I. Minina

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

MD, Leading Researcher of Cytogenetics Laboratory, 

Kemerovo

Russian Federation

L. A. Gordeeva

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

PhD (Candidate of Biology), Leading Researcher of Immunogenetics Laboratory,

Kemerovo

Russian Federation

S. A. Mun

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Author for correspondence.
Email: stellamun@yandex.ru

PhD (Candidate of Medicine), Senior Researcher Fellow of Immunogenetics Laboratory,

Kemerovo

Russian Federation

A. V. Ryzhkova

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

Leading Engineer-technologist of Cytogenetics Laboratory,

Kemerovo

Russian Federation

A. A. Glushkov

Novosibirsk State University, Institute of Medicine and Psychology

Email: fake@neicon.ru

Student,

Novosibirsk

Russian Federation

A. I. Rogozin

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

Postgraduate,

Kemerovo

Russian Federation

V. A. Lutsenko

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

Main Physician,

Kemerovo

Russian Federation

N. E. Verzhbitskaya

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

PhD (Candidate of Medicine), Chief of Path-anatomy Department,

Kemerovo

Russian Federation

I. A. Vafin

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

Main Physician,

Kemerovo

Russian Federation

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Copyright (c) 2019 Polenok E.G., Minina V.I., Gordeeva L.A., Mun S.A., Ryzhkova A.V., Glushkov A.A., Rogozin A.I., Lutsenko V.A., Verzhbitskaya N.E., Vafin I.A.

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