Email this article APPLICATION OF IN VITRO CULTURAL MODELS WITH INTERLEUKIN-7 FOR ESTIMATING THE FUNCTIONAL ACTIVITY OF T-LYMPHOCYTES
- Authors: Shmarov V.A.1, Goncharov A.G.1
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Affiliations:
- Immanuel Kant Baltic Federal University
- Issue: Vol 22, No 4 (2019)
- Pages: 1552-1554
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/971
- DOI: https://doi.org/10.31857/S102872210007087-0
- ID: 971
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Abstract
Currently, studies on the action of cytokines on the functional activity of immunocompetent cells are of great scientific interest. The most signifi ant is the use of various models of the immune system cells culture. This paper describes two cellular models used to study the direct effect of interleukin-7 on the functional properties of T-lymphocytes. Interleukin-7 (IL-7) is involved in the main stages of the T-cell life cycle: carrying out the signals necessary for survival, differentiation, proliferative activity, protection from apoptotic death, homeostatic maintenance of the number of T-lymphocytes. The directionality and severity of the effects of IL-7 was evaluated on the proposed homeostatic and activation T-cell models in vitro.
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About the authors
V. A. Shmarov
Immanuel Kant Baltic Federal University
Author for correspondence.
Email: enant@list.ru
Junior research fellow, Center for Medical Biotechnologies,
Kaliningrad
Russian FederationA. G. Goncharov
Immanuel Kant Baltic Federal University
Email: fake@neicon.ru
PhD, Deputy Director of the Medical Institute for Scientific Work,
Kaliningrad
Russian FederationReferences
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- Shmarov V. A., Malashchenko V. V., Meniailo M. E., Gaza tova N. D., Todosenko N. M., Melashchenko O. B., Goncharov A. G., Seledtsov V. I. Direct effects of interleukin-7 on the function of human T cells in vitro.Eur Cytokine Netw. 2016; 27(4), 102–107.
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