Сongenital immunity dysfunction in patients with postoperative cognitive impairment after coronary artery bypass grafting

Cover Page

Cite item

Abstract

With regard of post-surgical cognitive disturbances, an active search for biological markers of these neurological complications is performed. We have studied the contents of NSE, IL-6, TGF-β1, MMP9 and TIMP1 in blood serum of these patients. The study included 110 patients after aortal-coronary bypass surgery using extracorporeal blood circulation. Splitting into separate groups was based on the test scores, according to Montreal Cognitive Assessment Scale prior to surgery and on day +7 after the intervention: (I) patients without complications (< 3 points); (II) patients with post-surgical cognitive impairment (> 3 points). The comparison group (III) included 35 healthy subjects. Evaluation of NSE, IL-6, TGF-β1, ММP9 and TIMP1 in blood serum was performed by means of ELISA technique (R&D Systems, USA). The data were expressed as pg/ml, or ng/ml. Blood sampling was made at 4 terms: before surgery, just after intervention, 24 h later, and on day 7 after the surgery.
The patients from group II showed higher NSE levels, except of 7 days after surgery when it became similar to other groups. Increased IL-6 levels were found in the patients from group II at all terms after surgery. Decreased concentration of TGF-β1 was found in the II group prior to operation, 24 h and 7 days after the surgery. However, just after surgery, this index was increased, and its values barely differed from results of groups I and III. Studies of MMP9 showed significant differences between groups I and II only on day +7 after. However, lower MMP9 content was detected in the patients from I and II groups before surgery compared to group III. TIMP1 values showed gradual increase over the observation period, but did not differ between groups I and II. In the patients from group II, an increased content of NSE and IL-6 was revealed, along with low TGF-β1 levels and decreased ММP9/TIMP1 ratio over early postsurgical period, thus suggesting possible role of innate immunity dysfunction in pathogenesis of postsurgical cognitive impairment.

About the authors

E. V. Markelova

Pacific State Medical University

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Head, Department of Normal and Pathological Physiology

Vladivostok 

Russian Federation

A. A. Zenina

Pacific State Medical University;
Far Eastern Federal University

Author for correspondence.
Email: Zenina.aa@dvfu.ru

Postgraduate Student, Department of Normal and Pathological Physiology; Anesthesiologist-Resuscitator

690105, Russian Federation, Vladivostok, Nevelsky str., 1, apt 208

Phone: 7 (914) 707-26-52 

Russian Federation

A. A. Silaev

Far Eastern Federal University

Email: fake@neicon.ru

PhD (Medicine), Head, ICU Department

Vladivostok 

Russian Federation

E. A. Chagina

Pacific State Medical University

Email: fake@neicon.ru

PhD (Medicine), Associate Professor, Department of Normal and Pathological Physiology

Vladivostok 

Russian Federation

L. N. Fedyanina

Far Eastern Federal University

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Department of Fundamental Medicine, School of Biomedicine

Vladivostok 

Russian Federation

References

  1. Левин C.Г., Годухин О.В. Модулирующее действие цитокинов на механизмы синаптической пластичности в мозге // Биохимия, 2017. Т. 82, № 3. С. 397-409.
  2. Bogoslovsky T., Gill J., Jeromin A., Davis C., Diaz-Arrastia R. Fluid biomarkers of traumatic brain injury and intended context of use. Diagnostics (Basel), 2016, Vol. 6, no. 4, 37. doi: 10.3390/diagnostics6040037.
  3. Casault C., Al Sultan A.S., Banoei M., Couillard P., Kramer A., Winston B.W. Cytokine responses in severe traumatic brain injury: where there is smoke, is there fire? Neurocrit. Care, 2019, Vol. 30, no. 1, pp. 22-32.
  4. Evered L., Silbert B., Knopman D.S., Scott D.A., DeKosky S.T., Rasmussen L.S., Oh E.S., Crosby G., Berger M., Eckenhoff R.G. The Nomenclature Consensus Working Group Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery. Br. J.Anaesth., 2018, Vol. 121, no. 5, pp. 1005-1012.
  5. Jassam Y.N., Izzy S., Whalen M., McGavern D.B., El Khoury J. Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron, 2017. Vol. 95, no. 6, pp. 1246-1265.
  6. Lin X., Chen Y., Zhang P., Chen G., Zhou Y., Yu X. The potential mechanism of postoperative cognitive dysfunction in older people. Exp. Gerontol., 2020, Vol. 130, 110791. doi: 10.1016/j.exger.2019.110791.
  7. Rempe R.G., Hartz A.M., Bauer B. Matrix metalloproteinases in the brain and blood–brain barrier: versatile breakers and makers. J. Cereb. Blood Flow Metabol., 2016, Vol. 36, no. 9, pp. 1481-1507.
  8. Rothaug M., Becker-Pauly C., Rose-John S. The role of interleukin-6 signaling in nervous tissue. Biochim. Biophys. Acta, 2016, Vol. 1863, no. 6, Pt A, pp. 1218-1227.
  9. Silva F.P., Schmidt A.P., Valentin L.S., Pinto K.O., Zeferino S.P., Oses J.P. S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery. Eur. J. Anaesthesiol., 2016, Vol. 33, pp

Supplementary files

There are no supplementary files to display.


Copyright (c) 2021 Markelova E.V., Zenina A.A., Silaev A.A., Chagina E.A., Fedyanina L.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies