ROLE OF VISFATIN IN THE PATHOGENESIS OF INSULIN RESISTANCE


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Abstract

We have studied the tissue-specific features of the expression of the NAMPT gene encoding visfatin. In patients with obesity with type 2 diabetes, a violation of the insulin-protective mechanism of the effect of visfatin on tissue is recorded, which is confirmed by the positive correlations of the level of visfatin with leptin and insulin in the circulation.

About the authors

M. A. Vulf

Immanuel Kant Baltic Federal University Kaliningrad

Author for correspondence.
Email: mary-jean@yandex.ru

PhD, researcher of Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

D. A. Skuratovskaya

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD, researcher of Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

A. R. Soboleva

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

student at the Medical Institute,

Kaliningrad

Russian Federation

S. A. Stepanian

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

student at the Medical Institute,

Kaliningrad

Russian Federation

E. V. Kirienkova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD, researcher of Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

L. S. Litvinova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

MD, PhD Head of the Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

References

  1. Chang YH, Chang DM, Lin KC, Shin SJ, Lee YJ. Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review. Diabetes Metab Res Rev. 2011 Sep;27(6):515–27. doi: 10.1002/dmrr.1201.
  2. Wang SN, Miao CY. Targeting NAMPT as a therapeutic strategy against stroke. Stroke Vasc Neurol. 2019 Apr 5;4(2):83–89. doi: 10.1136/svn-2018-000199.
  3. Lin YT, Chen LK, Jian DY, Hsu TC, Huang WC, Kuan TT, Wu SY, Kwok CF, Ho LT, Juan CC. Visfatin Promotes Monocyte Adhesion by Upregulating ICAM-1 and VCAM-1 Expression in Endothelial Cells via Activation of p38-PI3K-Akt Signaling and Subsequent ROS Production and IKK/NF-κB Activation. Cell Physiol Biochem. 2019;52(6):1398–1411. doi: 10.33594/000000098.

Copyright (c) 2019 Vulf M.A., Skuratovskaya D.A., Soboleva A.R., Stepanian S.A., Kirienkova E.V., Litvinova L.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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