PGC-1α in human CD4+T cell subsets

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CD4+T lymphocyte pool is heterogeneous in nature consisting of distinct subsets. The functional activity of each subset is highly influenced by how its energy metabolism is controlled. In naïve, central memory, effector memory, and TEMRA CD4+T cells received from healthy volunteers aged 29-42 years we evaluated the level of the major cell energy metabolism regulator: transcriptional coactivator PGC-1α. PGC-1α was shown to be expressed in all CD4+T cells. Its level in central memory, effector memory, and TEMRA cells was higher than that in naïve cells for both conventional and regulatory CD4+T lymphocytes. Moreover, its level was found to be higher in conventional when compared with regulatory CD4+T cells. Our findings suggest that regulatory and conventional CD4+T cells rely on PGC-1α to a different extent. Apparently, PGC-1α is an important but not the only factor influencing the functional state of mitochondria in regulatory CD4+T lymphocytes.

About the authors

V. V. Vlasova

Institute of Ecology and Genetic of Microorganisms, Ural Branch, Russian Academy of Sciences, Branch of Perm Federal Research Center, Ural Branch, Russian Academy of Sciences

Author for correspondence.

Vlasova Violetta V. - Assistant, Laboratory of Ecological Immunology

614081, Perm, Golev str., 13.

Phone: 7 (324) 280-92-11 

Russian Federation

N. G. Shmagel

Institute of Ecology and Genetic of Microorganisms, Ural Branch, Russian Academy of Sciences, Branch of Perm Federal Research Center, Ural Branch, Russian Academy of Sciences


PhD, MD (Medicine), Senior Research Associate, Laboratory of Ecological Immunology


Russian Federation


  1. Dimeloe S., Mehling M., Frick C., Loeliger J., Bantug G.R., Sauder U., Fischer M., Belle R., Develioglu L., Tay S., Langenkamp A., Hess C. The Immune-metabolic basis of effector memory CD4+ T cell function under hypoxic conditions. J. Immunol., 2016, Vol. 196, no. 1, pp. 106-114.
  2. Feige J.N., Auwerx J. Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol., 2007, Vol. 17, no. 6, pp. 292-301.
  3. Handschin C., Spiegelman B.M. Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev., 2006, Vol. 27, no. 7, pp. 728-735.
  4. He N., Fan W., Henriquez B., Yu R.T., Atkins A.R., Liddle C., Zheng Y., Downes M., Evans R.M. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. Proc. Natl. Acad. Sci. USA, 2017, Vol. 114, no. 47, pp. 12542-12547.
  5. Howie D., Cobbold S.P., Adams E., Ten Bokum A., Necula A.S., Zhang W., Huang H., Roberts D.J., Thomas B., Hester S.S., Vaux D.J., Betz A.G., Waldmann H. FOXP3 drives oxidative phosphorylation and protection from lipotoxicity. JCI insight, 2017, Vol. 2, no. 3, e89160. doi: 10.1172/jci.insight.89160.
  6. Jameson S.C., Masopust D. Understanding subset diversity in T cell memory. Immunity, 2018, Vol. 48, no. 2, pp. 214-226.
  7. Lehman J.J., Barger P.M., Kovacs A., Saffitz J.E., Medeiros D.M., Kelly D.P. Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest., 2000, Vol. 106, no. 7, pp. 847-856.
  8. Michalek R.D., Gerriets V.A., Jacobs S.R., Macintyre A.N., MacIver N.J., Mason E.F., Sullivan S.A., Nichols A.G., Rathmell J.C. Cutting edge: Distinct Glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+T cell subsets. J. Immunol., 2011, Vol. 186, no. 6, pp. 3299-3303.
  9. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol., 1995, Vol. 155, no. 3, pp. 1151-1164.
  10. Sena L.A., Li S., Jairaman A., Prakriya M., Ezponda T., Hildeman D.A., Wang C.-R., Schumacker P.T., Licht J.D., Perlman H., Bryce P.J., Chandel N.S. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity, 2013, Vol. 38, no. 2, pp. 225-236.
  11. Vega R.B., Huss J.M., Kelly D.P. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol., 2000, Vol. 20, no. 5, pp. 1868-1876.
  12. Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell, 1999, Vol. 98, no. 1, pp. 115-124.

Copyright (c) 2020 Vlasova V.V., Shmagel N.G.

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