Assessment of the role of WIF-1 in the genesis of ischemic heart disease

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Abstract

Coronary heart disease poses one of the most serious threats to human health resulting in enormous physical and economic losses worldwide. WNT signaling pathways play an important role in cardiogenesis both in embryogenesis and cardiac repair after previous ischemic attacks that motivated to conduct this study.
The aim of the study was to examine features of WIF-1 production in patients with coronary heart disease. There were enrolled 60 patients with a clinically verified and diagnosed coronary artery disease. WIF-1 serum concentration was measured by using enzyme-linked immunosorbent assay presenting data as absolute numbers (n, %) or medians, 1 and 3 quartiles – Me (Q0.25-Q0.75). Analyzing study data showed that WIF-1 serum concentration in patients with myocardial infarction was 2890 (1700-3337.5) pg/ml being by 7.97-fold higher than that one in healthy individuals (p <0.001), in agreement with previous studies. Moreover, in patients with angina pectoris WIF-1 serum level comprised 2170 (1493-2650) pg/ml, exceeding that one in healthy individuals by 6.14-fold (p < 0.001). Thus, the data obtained regarding changes in serum WNT-inhibiting factor-1 concentration in patients with coronary heart disease expand our understanding about an impact from affected WNT-signaling pathway components in pathogenesis of inflammatory process during hypoxic injuries.

About the authors

M. O. Plotnikova

I. Turgenev Oryol State University

Author for correspondence.
Email: ekb-lem@mail.ru

Plotnikova Maria O. - Senior Lecturer, Department of Immunology and Specialized Clinical Disciplines

302026, Oryol, Komsomolskaya str., 95

Phone: 7 (905) 802-15-39

Russian Federation

I. A. Snimshchikova

I. Turgenev Oryol State University

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Head, Department of Immunology and Specialized Clinical Disciplines, Director of Medical Institute

Oryol

Russian Federation

I. A. Afoninа

I. Turgenev Oryol State University

Email: fake@neicon.ru

PhD (Medicine), Associate Professor, Department of Immunology and Specialized Clinical Disciplines

Oryol

Russian Federation

A. S. Kulakova

Bryansk Regional Hospital No. 1

Email: fake@neicon.ru

Gastroenterologist

Bryansk

Russian Federation

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Copyright (c) 2020 Plotnikova M.O., Snimshchikova I.A., Afoninа I.A., Kulakova A.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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