Email this article INFLUENCE OF METHYLPREDNISOLON ON THE ACTIVATION OF TCR-STIMULATED CD4+CD45RO+ T-LYMPHOCYTES IN PATIENTS WITH RHEUMATOID ARTHRITIS IN THE SYSTEM IN VITRO
- Authors: Todosenko N.M.1, Yurov C.A.1, Haziahmatova O.G.1, Litvinova L.S.1
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Affiliations:
- Baltic Federal University. Kant
- Issue: Vol 20, No 3 (2017)
- Pages: 534-536
- Section: Articles
- Submitted: 22.10.2020
- Published: 15.07.2017
- URL: https://rusimmun.ru/jour/article/view/757
- ID: 757
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Abstract
The effect of methylprednisolone (MP) on the functional activity of CD4+ CD45RO+ T cells obtained in patients with rheumatoid arthritis (RA) and healthy donors in the in vitro system was studied. It has been shown that MP significantly reduces the number of TCR-activated СD4+СD45RO+СD25+ and СD4+СD45RO+СD71+ T-lymphocytes in cultures of RA patients and in healthy donors. MP, reducing the number of СD4+СD28+ T cells, promotes the formation of terminal-differentiated memory effector T-cells.
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About the authors
N. M. Todosenko
Baltic Federal University. Kant
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
C. A. Yurov
Baltic Federal University. Kant
Email: noemail@neicon.ru
Russian Federation
O. G. Haziahmatova
Baltic Federal University. Kant
Email: noemail@neicon.ru
Russian Federation
L. S. Litvinova
Baltic Federal University. Kant
Email: noemail@neicon.ru
Russian Federation
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- СD45RA-Foxp3(high) activated/effectoг regulator T cells in the CCR 7+СD45RA-СD27+СD28+centгal memo^ subset are decreased in peripheral blood from patients with Theumatoid arthritis. /F. Matsu-ki, J. Saegusa, Y. Miyamoto et. al.//Biochem Biophys Res Commun.- 2013.- Vol. 6; № 438 - р. 778-83.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).