Relation between TNFα and S100B in patients with herpes zoster and postherpetic neuralgia

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Abstract

One of the most important components in the pathogenesis of herpes zoster and postherpetic neuralgia is presented by disturbed neuroimmune interaction, characterized by development of chronic inflammation in the nervous system structures. Normally existing interaction between immune and nervous systems is altered and results in development of pathological system. Altered level of TNFα and S100B proteins may characterize the features of neuroimmune inflammation during herpes zoster infection. Objective: to assess a relationship between TNFα and S100B level in patients with herpes zoster and postherpetic neuralgia. We examined 106 patients with herpes zoster within the framework of our study. Based on assessing intensity of pain syndrome and its three-month follow-up data after primary treatment patients were subdivided into 3 main groups: group I – weak or moderate pain syndrome; group II – severe pain syndrome; group III – postherpetic neuralgia. The control group contained 30 age-matched apparently healthy volunteers. Venous blood sampling was performed twice: on day 1 and day 10 after disease onset. Biological material in control group was collected once. Level of blood serum TNFα and S100B was measured by using solid-phase enzyme immunoassay (ELISA) on analyzer “Multiscan”. While assessing TNFα level in all three main groups, its lowered level was detected (p < 0.05) on day 1, without finding inter-group differences. On day 10 after disease onset, level of TNFα did not differ from the control values found in groups I and II, while in group III it remained lowered, not being significantly differed from those found on day 1. Level of S100B in the blood serum in patients vs. control group was equivalently increased (p < 0.05), showing no inter-group differences. On day 10, the level of S100B in the blood serum from patients of groups I and II tended to stabilize, by decreasing almost by 2-fold to reference intervals in group I, without reaching control values, in group II. Patients from group III were found to have serum level of S100B remained elevated compared to control group without dynamic changes between 1 and 10 days. A correlation analysis for TNFα and s100b protein revealed significant feedback relation between them (p < 0.05) in group III.

About the authors

S. V. Knysh

Pacific State Medical University

Author for correspondence.
Email: immunolog.vl@gmail.com

Knysh Sergey V. - Assistant Professor, Department of Normal and Pathological Physiology

690105, Vladivostok, Russkaya str., 57k, apt 107

Phone: 7 (995) 773-65-23

Russian Federation

T. A. Nevezhkina

Pacific State Medical University

Email: fake@neicon.ru

Assistant Professor, Department of Normal and Pathological Physiology

Vladivostok

Russian Federation

A. V. Kostyushko

Pacific State Medical University

Email: fake@neicon.ru

PhD (Medicine), Associate Professor, Department of Normal and Pathological Physiology

Vladivostok

Russian Federation

P. S. Ilyina

Pacific State Medical University

Email: fake@neicon.ru

Student, General Medicine Faculty

Vladivostok

Russian Federation

References

  1. Караулов А.В., Сокуренко С.И., Калюжин О.В., Евсегнеева И.В. Направленная регуляция иммунных реакций в профилактике и лечении заболеваний человека // Иммунопатология, аллергология, инфектология, 2000. № 1. С. 7-13. [Karaulov A.V., Sokurenko S.I., Kalyzhin O.V., Yevsegneeva I.V. Directed regulation of immune reactions in preventing and treating human diseases. Immunopatologiya, allergologiya, infektologiya = Immunopathology, Allergology, Infectology, 2000, no. 1, pp. 7-13. (In Russ.)]
  2. Foltran R.B., Diaz S.L. BDNF isoforms: a round trip ticket between neurogenesis and serotonin? J. Neurochem., 2016, Vol. 138, no. 2., pp. 204-221.
  3. Marra F., Parhar K., Huang B., Vadlamudi N. Risk factors for herpes zoster infection: a meta-analysis. Open Forum Inf. Dis., 2020, Vol. 7, no. 1, ofaa005. doi: 10.1093/ofid/ofaa005.
  4. Sante D.G., Amadio S., Sampaolese B., Clementi M.E., Valentini M., Volonte C., Casalbore P., Michetti F. The S100B inhibitor pentamidine ameliorates clinical score and neuropathology of relapsing-remitting multiple sclerosis mouse model. Cells, 2020, Vol. 9, no. 3, 748. doi: 10.3390/cells9030748.
  5. Sorci G., Riuzzi F., Arcuri C., Tubaro C., Bianchi R., Giambanco I., Donato R. S100B protein in tissue development, repair and regeneration. World J. Biol. Chem., 2013, Vol. 4, no. 1, pp. 1-12. doi: 10.4331/wjbc.v4.i1.1.
  6. Steain M., Baker M.O.D.G., Pham C.L.L., Shanmugam N., Gambin Y., Sierecki E., McSharry B.P., Avdic S., Slobedman B., Sunde M., Abendroth A. Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death. PLoS Pathog., 2020, Vol. 16, no. 7, e1008473. doi: 10.1371/journal.ppat.1008473.
  7. Winthrop K.L., Baddley J.W., Chen L., Liu L., Grijalva C.G., Delzell E., Beukelman T., Patkar N.M., Xie F., Saag K.G., Herrinton L.J., Solomon D.H., Lewis J.D., Curtis J.R. Association between the initiation of anti-tumor necrosis factor therapy and the risk of herpes zoster. JAMA, 2013, Vol. 309, no. 9, pp. 887-895.
  8. Zhang P., Tan C.-W., Chen G.-H., Ge Y.-J., Xu J., Xia L. Fang W., Li X.-Y., Kong X.-Y. Patients with chronic insomnia disorder have increased serum levels of neurofilaments, neuron-specific enolase and S100B: does organic brain damage exist? Sleep Med., 2018, Vol. 48, pp. 163-171.

Copyright (c) 2020 Knysh S.V., Nevezhkina T.A., Kostyushko A.V., Ilyina P.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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