METABOLISM OF THE LYMPHOCYTE POPULATIONS IN THE OUTCOME OF REPEAT CORNEAL TRANSPLANTATION


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Abstract

In the study estimation of the informative defination of the activity ratio of mitochondrial dehydrogenases glycerol-3-phosphate (GPDG) and succinate (SDG) in the major populations of lymphocytes to predict graft rejection at the 15 recipients of the group’s risk before rekeratoplasty. An increase in the ratio of GPDG/SDG activity in all major lymphocyte populations, most pronounced in B-lymphocytes and NK- cells, was found in patients with adverse outcome. The ratio of activity GPDG/SDG can serve as a prognostic indicator of graft rejection in keratoplasty.

About the authors

Y. A. Komakh

The S. Fyodorov Eye Microsurgery Federal State Institution

Author for correspondence.
Email: komakh@yandex.ru

Ph.D., Head of the Transplantology and Cellular Biology Laboratory,

Moscow

Russian Federation

S. A. Borzenok

The S. Fyodorov Eye Microsurgery Federal State Institution

Email: fake@neicon.ru

M.D., Ph.d., Prof., Head of the Center of Fundamental and Applied Medical and Biological Problems,

Moscow

Russian Federation

T. V. Radygina

FSAI «Scientific Center of Children´s Health»

Email: fake@neicon.ru

Ph.D. (Medicine), Senior Research Associate, Laboratory of Experimental Immunology and Virology,

Moscow

Russian Federation

S. V. Petrichuk

FSAI «Scientific Center of Children´s Health»

Email: fake@neicon.ru

PhD, MD (Biology), Professor, Main Research Associate, Laboratory of Experimental Immunology and Virology,

Moscow

Russian Federation

D. G. Gerasimova

FSAI «Scientific Center of Children´s Health»

Email: fake@neicon.ru

intern oftheLaboratory of Experimental Immunology and Virology,

Moscow

Russian Federation

References

  1. Комах Ю. А., Борзенок С. А., Петричук С. В., Самохина И. В. Реакция отторжения трансплантата роговицы: клинико-анамнестические и иммунологические критерии диагностики. Российский иммунологический журнал 2017,4; 11 (20), 714– 716.
  2. Angajala A., Lim S., Phillips J. B., Kim J.-H., Yates Cl., You Z., Tan M. Diverse roles of mitochondria in immune responses: novel insights into immune-metabolism. Frontiers in immunology, 2018,9; 1805, 1–19.
  3. Ron-Harel N., Sharpe A. H., Haigis M. C. Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review. Gerontology. 2015; 61,131–138.
  4. Патент 2302635 РФ, МПК G01 № 33/53, G01 № 33/50 Способ измерения митохондриальной активности лимфоцитов / С. В. Петричук, Т. Д. Измайлова, Т. В. Радыгина; заявитель и патентообладатель Государственное учреждение Научный центр здоровья детей РАМН. – № 2005141145/15; заявл. 28.12.2005; опубл. 10.07.2007.

Copyright (c) 2019 Komakh Y.A., Borzenok S.A., Radygina T.V., Petrichuk S.V., Gerasimova D.G.

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