DETERMINATION OF THE LEVEL OF CD64 ON NEUTROFILES IN PATIENTS WITH SURGICAL SEPSIS


Cite item

Abstract

The level of the expression of CD64 on neutrophils by fl ow cytometry in 49 patients with sepsis was studied, the dependence of these parameters on the degree of severity of the condition on the scale APACHEII (in points), the severity of multiple organ dysfunction scale SOFA (in points).High-level of expression on neutrophils nCD64 directly correlated with more severe organ dysfunction (SOFA), the weight of the state (APACHEII). These results may give the suggestion that presence of CD64 on neutrophils may serve as a biomarker refl ecting on the degree of systemic infl ammation in sepsis and may be a criterion in the prediction of the severity of disease and outcome in patients with sepsis.

About the authors

V. A. Lazanovich

Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation

Author for correspondence.
Email: immuno2003@mail.ru

Ph.D., assistant professor, Department of normal and Pathological Physiology,

Vladivostok

Russian Federation

A. V. Кostyushko

Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation

Email: fake@neicon.ru

Ph.D., assistant professor, Department of normal and Pathological Physiology, 

Vladivostok

Russian Federation

V. B. Shumatov

Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation

Email: fake@neicon.ru

Doctor of Sciences, Professor of the Department of intensive care, anesthesiology, intensive care and emergency medical services, 

Vladivostok

Russian Federation

References

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  2. Icardi M., Erickson Y., Kilborn S. et al. CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J. Clin. Microbiol. 2009; (47): 3914–3919.
  3. Singer M., Deutschman S., Seymour C. W., ShankarHari M., Annane D., Bauer M et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8), 801–810.
  4. Stevenson E. K., Rubenstein A. R., Radin G. T., Wiener R. S., Walkey A. J. Two decades of mortality trends among patients with severe sepsis: a comparative metaanalysis. Crit Care Med. 2014;42, 625–631.
  5. Venet F., Lepape A. Clinical review: flow cytometry perspectives in the ICU – from diagnosis of infection to monitoring of injury-induced immune dysfunctions. Crit. Care. 2011; 15(5), 231.

Copyright (c) 2019 Lazanovich V.A., Кostyushko A.V., Shumatov V.B.

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