INTERLEUKIN-8 POTENTIATED THE PRO-INFLAMMATORY ACTIVITY OF HUMAN MONOCYTES/MACROPHAGES AND T-LYMPHOCYTES


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Abstract

We investigated the direct effect of interleukin-8 (IL-8) on the functional activity of human monocytes/macrophages and T-lymphocytes. It was shown that IL-8enhanced the production of IL-6 and IL-1β by LPS-activated monocytes/macrophages. In addition, IL-8 enhanced the production of IL-2 and suppressed the production of IL-10 and IL-4 by activated T-lymphocytes. The results demonstrate the ability of IL-8 to stimulate both the pro-inflammatory (M1) activity of monocytes/macrophages, and to participate in the direct regulation of adaptive T-cell responses.

About the authors

M. E. Meniailo

Immanuel Kant Baltic Federal University

Author for correspondence.
Email: max89me@yandex.ru

PhD, Researcher of Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

Russian Federation

V. V. Malashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher of Center of Medical Biotechnology, 

Kaliningrad

Russian Federation

O. B. Melashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher of Center of Medical Biotechnology,

Kaliningrad

Russian Federation

E. O. Shunkin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

junior researcher of Center of Medical Biotechnology,

Kaliningrad

Russian Federation

A. G. Goncharov

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Deputy Director of the Medical Institute for Scientific Work,

Kaliningrad

Russian Federation

References

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  2. Hirahara K., Nakayama T. CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. International immunology. 2016, 28(4), 163–171.
  3. Meniailo M. E., Malashchenko V. V., Shmarov V. A., Gazatova N. D., Melashchenko O. B., Goncharov A. G., Seledtsova G. V., Seledtsov V. I. Direct effects of interleukin-8 on growth and functional activity of T lymphocytes. International immunopharmacology. 2017, 50, 178–185.
  4. Arango Duque G., Descoteaux A. Macrophage cytokines: involvement in immunity and infectious diseases. Frontiers in immunology.2014, 5, 491.
  5. Hwang E. S., Hong J. H., Glimcher L. H. IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. Journal of experimental medicine. 2005, 202(9), 1289–1300.

Copyright (c) 2019 Meniailo M.E., Malashchenko V.V., Melashchenko O.B., Shunkin E.O., Goncharov A.G.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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