DYNAMICS OF CYTOKINE LEVELS IN BLOOD SERUM IN PATIENTS WITH METABOLIC SYNDROME USING STATINS


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Abstract

The purpose of this research is to study the dynamics of the content in serum of IL-1β, IL-1α, IL-1ra, IL-18, IL-18BP, IL-37, IL-6, sIL-6r, LIF, sLIFr, IGF-1, TNF-α, sTNF -RI, IL-17, IL-2, IL-4, IL-10, TGF-β1, IL-8, CX3CL1, CXCL10, INFγ, M-CSF, IL-34, VEGF-A, EPO in patients with metabolic syndrome (MS) using statins. The use of statins for 6 months in patients with MS is characterized by a decrease in M-CSF to 399 [375–440] pg / ml (p <0.001) with a secondary increase in the concentration of the protective factor – sertuina-1 (p<0.001) and HDL, that blocks progression of atherosclerotic processes. The concentration of M-CSF in the range [395–454] pg / ml cancels its stimulating effect to synthesis of VEGF-A and slows the growth of coronary collaterals that maintaining a high risk of myocardial infarction (this effect is leveled when using statins for more than 6 months). The data obtained confirm the relevance of further research in this direction.

About the authors

O. A. Radaeva

National Research Mordovia State University

Author for correspondence.
Email: radaevamed@mail.ru

PhD, docent of chair of Immunology, Microbiology, Virology, 

Saransk

Russian Federation

A. S. Simbirtsev

State Research Institute of Highly Pure Biopreparations, FMBA

Email: fake@neicon.ru

RAS Corresponding Member, DMedSci, Professor, Scientific Supervisоr,

St. Petersburg

Russian Federation

Yu. A. Kostina

National Research Mordovia State University

Email: fake@neicon.ru

PhD, docent of chair of Immunology, Microbiology, Virology,

Saransk

Russian Federation

M. S. Iskandyarova

National Research Mordovia State University

Email: fake@neicon.ru

assistant of chair of Immunology, Microbiology, Virology,

Saransk

Russian Federation

References

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  2. Zeiser R. Immune modulatory effects of statins. Immunology. 2018;154(1), 69–75.
  3. Радаева О. А., Симбирцев А. С. М-CSF, IL-34, VEGF-A как факторы риска развития инфаркта миокарда, острого нарушения мозгового кровообращения у больных эссенциальной артериальной гипертензией. Российский иммунологический журнал. 2015; 9(18). № 1, 93–101.
  4. Okazaki T., Ebihara S., Asada M., Yamanda S., Saij o Y., Shiraishi Y., Ebihara T., Niu K., Mei H., Arai H., Yambe T. Macrophage colony-stimulating factor improves cardiac function after ischemic injury by inducing vascular endothelial growth factor production and survival of cardiomyocytes. Am. J. Pathol. 2007; 171, 1093–1103.

Copyright (c) 2019 Radaeva O.A., Simbirtsev A.S., Kostina Y.A., Iskandyarova M.S.

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