OROPHARYNGEAL CANDIDIASIS: ETIOLOGY, RISK FACTORS AND IMMUNOPATHOLOGY OF DEVELOPMENT IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES



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Abstract

Despite the existing immunoreactivity defects in patients with hemoblastosis, the reasons of the relatively low incidence of oropharyngeal candidiasis (OPC) remain unclear. Among the 525 observed patients with hemoblastosis, in 137 of them werenoted clinical signs of OPC. Of these, in 51 patients (9.7%) OPC was verified. The probability of OPC occurrence significantly increased with the use of antibacterial therapy. The OPC development was accompanied by an increase of IL-6, IL-8, SLPI, DEFb2 and a decrease of IL-17 and MCP-1 in the oral fluid, indicating insufficient functional activity of monocytemacrophage cells, as well as regulators of T-cell response in the oral mucosa.

About the authors

N. V. Shabashova

North-Western State Medical University named after I. I. Mechnikov

Author for correspondence.
Email: shabashova@bk.ru

PhD, Professor of Department of Clinical Mycology, Allergology and Immunology,

Saint-Petersburg

Russian Federation

E. V. Frolova

North-Western State Medical University named after I. I. Mechnikov

Email: fake@neicon.ru

PhD, Head of the Laboratory of Immunology and Allergology Kashkin Research Institute of MedicalMycology,

Saint-Petersburg

Russian Federation

L. V. Filippova

North-Western State Medical University named after I. I. Mechnikov

Email: fake@neicon.ru

PhD, Senior Researcher of Immunology and Allergology Kashkin Research Institute of MedicalMycology,

Saint-Petersburg

Russian Federation

A. E. Uchevatkina

North-Western State Medical University named after I. I. Mechnikov

Email: fake@neicon.ru

PhD, Senior Researcher of Immunology and Allergology Kashkin Research Institute of MedicalMycology,

Saint-Petersburg

Russian Federation

References

  1. Gligorov J., Bastit L., Gervais H. Prevalence and treatment management of oropharyngeal candidiasis in cancer patients: results of the French Candidoscope study. IntJRadiatOncolBiolPhys. 2011, 80(2), 532–539.
  2. Данилова Е.Ю., Шабашова Н. В., Фролова Е. В., Учеваткина А. Е., Филиппова Л. В. Особенности местной защиты онкогематологических больных при орофарингеальном кандидозе. Иммунопатология, аллергология, инфектология. 2015, 3, 31–39.
  3. Verma A. H., Richardson J P., Zhou Ch., Coleman B. M., Moyes D. L., Ho J., Huppler A. R., Ramani K., McGeachy M. J., Mufazalov I. A., Waisman A., Kane L. P., Biswas P. S., Hube B., Naglik J. R., Gaff en S. L. Oral epithelial cells orchestrate innate Type 17 responses to Candida albicans through the virulence factor Candidalysin Sci Immunol. 2017, 3; 2(17), eaam8834.

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Copyright (c) 2019 Shabashova N.V., Frolova E.V., Filippova L.V., Uchevatkina A.E.

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