CHARACTERISTICS OF THE IMMUNE RESPONSE IN PATIENTS WITH POSTCOVID SYNDROME AND AN ANAMNESIS OF TYPE 6 HERPES



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Abstract

Abstract

Since the end of 2019, people have been faced with a coronavirus infection, which is a disease caused by a new strain of coronavirus – SARS-CoV-2. This disease has led to one of the global problems of mankind – a pandemic. Despite the fact that the clinical manifestations of COVID-19 over time acquired features characteristic of seasonal viral infections, persistent disturbances in the functioning of various body systems were identified. It was found that after suffering from COVID-19, a significant number of patients experience numerous deteriorations in both general health and complications of existing chronic diseases, including herpesvirus infection and papillomavirus infection. In this regard, the scientific community has an additional task – a comprehensive and in-depth study of post-COVID syndrome to identify ways to improve the condition of patients.

Currently, it has been revealed that about 90% of the world's population is infected with herpes viruses. In some cases, one person may be found to have several types of herpes viruses, which is called coinfection. Herpesvirus infection can manifest itself from local labial herpes to generalized forms, malignant neoplasms and congenital malformations. It can occur both in acute and latent forms. The study of herpesvirus infection in the context of post-covid syndrome is one of the most pressing problems of modern medicine.

The purpose of this study was to study the features of changes in immune response indicators in patients with post-covid syndrome and with laboratory and clinically confirmed herpes virus type 6, and for this purpose, changes in innate immune response indicators such as the complement system, phagocytic activity of neutrophils were provided.

Clinical, immunological (enzyme-linked immunosorbent assay and NBT test (nitroblue tetrazolium)) and statistical analysis methods (Mann-Whitney criterion) were used for the study. The data indicating that adverse reactions caused by the previous coronavirus infection are characterized by new aspects manifested in disorders of the acquired and innate immune systems, which leads to more serious consequences for the immune system and the body as a whole, have been carefully studied and analyzed.

The revealed changes indicate that the most pronounced transformations are observed in patients with post-COVID syndrome and a history of herpes virus type 6. This highlights the need for a more detailed study of their immune status in order to develop individualized approaches to immunocorrection of immune system disorders in this group of patients, taking into account their herpesvirus history.

About the authors

Maria Verkhovskaya

FBIS Scientific Research Institute of Viral Infections «VIROM» Federal Service for Supervision of Consumer Rights Protection and Human Consumption, Yekaterinburg

Email: maria.verh1@mail.ru
ResearcherId: HRD-1823-2023
https://www.elibrary.ru/author_profile.asp?id=1188448

Junior researcher at the laboratory of transmissible viral infections of the Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections «Virome» Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing, Yekaterinburg

Russian Federation, 620030, Russia, Yekaterinburg, Letnaya street, 23

Violetta Sergeevna Marchenko

Federal State Budgetary Educational Institution of Higher Education «Chelyabinsk State University», Chelyabinsk

Author for correspondence.
Email: violetkakonfetka01@gmail.com

student of the faculty of fundamental medicine, specialty "medical biochemistry"

Russian Federation, 454001, Chelyabinsk region, Chelyabinsk, Brothers Kashirin street, 129

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