Email this article COMPARATIVE CHARACTERIZATION OF MMR-9 AND TIMP-1 PRODUCTION BY DIFFERENT MACROPHAGES SUBSETS
- Authors: Yankovskaya A.A.1, Sakhno L.V.1, Shevela E.Y.1
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Affiliations:
- Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
- Issue: Vol 22, No 2-2 (2019)
- Pages: 997-998
- Section: ORIGINAL ARTICLES
- Submitted: 04.08.2020
- Accepted: 04.08.2020
- Published: 15.07.2019
- URL: https://rusimmun.ru/jour/article/view/444
- DOI: https://doi.org/10.31857/S102872210006493-7
- ID: 444
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Abstract
The paper presents a comparative characterization of the MMP-9 and TIMP-1 production by various subsets of macrophages (Mφ) differentiated in the presence of GM-CSF and polarized into M1, M2a and M2c cells. It was shown that all the studied Mφ subtypes produced both MMP-9 and TIMP-1. At the same time, the MMP-9 / TIMP-1 ratio was signifi cantly higher in M2c Mφ compared to M1 and M2a, which may indicate the important role of M2c macrophages during tissue remodeling and restriction of fibrosis.
About the authors
A. A. Yankovskaya
Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
Author for correspondence.
Email: shevelak@mail.ru
graduate student of the Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationL. V. Sakhno
Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
PhD (Biology), Senior Research Associate, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationE. Ya. Shevela
Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
Email: shevelak@mail.ru
PhD, MD (Medicine), Leading Research Associate, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationReferences
- Braga T., Agudelo J., Camara N. Macrophages During the Fibrotic Process: M2 as Friend and Foe. Front Immunol. 2015, 25; 6, 602.
- Robert S., Gicquel Т., Victoni T., Valença S., Barreto E., Bailly-Maître B, Boichot E., Lagente V. Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis. Biosci Rep. 2016, 36, 4; e00360.
- Gensel J. C., Zhang B. Macrophage activation and its role in repair and pathology after spinal cord injury. Brain Res. 2015, 4;1619, 1–11.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).