MARKERS OF INFLAMMATION AND OXIDATIVE STRESS IN THE TREATMENT OF ACUTE ISCHEMIA OF THE LOWER LIMBS

Acute ischemia occurs due to obstruction of blood circulation, causing oxidative stress and tissue destruction. Restoration of blood flow ‒ reperfusion syndrome ‒ tissue antigens rush into the bloodstream, increasing the production of ROS and stimulating inflammation. The purpose of the work is to determine the relationship of oxidative stress, inflammation with the severity and outcome of the disease. 44 patients with acute ischemia of the lower limbs and basic therapy were observed. Studied the change in the process of treating blood oxidative activity by the level of chemiluminescence, total antioxidant activity plasma, C-reactive protein level as a marker of inflammation and creatine kinase, reflecting tissue damage, white blood cell count with leukogram count and neutrophilic lymphocyte ratio. Acute ischemia of the lower limbs is accompanied by destruction of tissues and an increase in ROS production, a decrease in total antioxidant activity, and an increase in systemic inflammation during the reperfusion period. With an increase in the severity of the disease, an increase in oxidative stress is observed, which exacerbates the destruction of tissues and provokes a further increase in the systemic inflammatory response.

Acute limb ischemia, oxidant and antioxidant activity, markers of infl ammation