METHODOLOGICAL APPROACHES TO IDENTIFICATION OF PECULIARITIES OF GENETIC POLYMORPHISM AS MARKERS OF EARLY VIOLATIONS OF IMMUNE REGULATION IN CONDITIONS OF CHRONIC EXPOSITION TO CHEMICAL FACTORS

O. V. Dolgikh; Долгих О. В.; N. V. Zaitseva; Зайцева Н. В.; A. V. Krivtsov; Кривцов А. В.; D. G. Dianova; Дианова Д. Г.; E. A. Otavina; Отавина Е. А.; N. V. Bezruchenko; Безрученко Н. В.; M. A. Guselnikov; Гусельников М. А.

METHODOLOGICAL APPROACHES TO IDENTIFICATION OF PECULIARITIES OF GENETIC POLYMORPHISM AS MARKERS OF EARLY VIOLATIONS OF IMMUNE REGULATION IN CONDITIONS OF CHRONIC EXPOSITION TO CHEMICAL FACTORS

Authors: Dolgikh O.V.¹, Zaitseva N.V.¹, Krivtsov A.V.¹, Dianova D.G.¹, Otavina E.A.¹, Bezruchenko N.V.¹, Guselnikov M.A.¹
Affiliations:
1. FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Issue: Vol 20, No 3 (2017)
Pages: 369-371
Section: Articles
Submitted: 22.10.2020
Published: 15.07.2017
URL: https://rusimmun.ru/jour/article/view/689
ID: 689

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Abstract

The use of targeted gene sequencing (Roche 454 sequencer) in the patients-representatives of European ethnicity with an excessive amount of strontium in the blood made it possible to detect the presence of a significant number of point replacements in 10 genes: MTHFR - gene of methylenetetrahydrofolate reductase (23 replacements); SULT1A1 - sulfransferase gene (41 replacement); SIRT3 - sirtuin gene (13 replacements); NOS 3 - gene of endothelial NO- synthase (19 replacements), and PPARD - receptor gene (6 replacements), activated by peroxisome proliferator: TERT - telomerase gene (14 replacements); FAS -gene of the death receptor (9 replacements); FOXP3 - transcriptional factor of cellular suppression (4 replacements); TP53 - transcriptional factor of onco suppression (7 replacements); VEGF - gene of vascular endothelial growth factor (8 replacements). Sites of these genes can be proposed as markers to manifest the harm to health caused by chemical factors.

Keywords

ген FAS, ген FOXP3, ген TERT, gen FAS, gen FOXP3, gen TERT

References

Долгих О.В., Кривцов А. В., Лыхина Т. С., Бубнова О. А., Ланин Д. В., Вдовина Н.А, Лужецкий К. П., Андреева Е. Е. Особенности иммуногенетических показателей у работников предприятия цветной металлургии // Гигиена и санитария.- 2015.- Т. 94, № 2.- С. 54-57

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METHODOLOGICAL APPROACHES TO IDENTIFICATION OF PECULIARITIES OF GENETIC POLYMORPHISM AS MARKERS OF EARLY VIOLATIONS OF IMMUNE REGULATION IN CONDITIONS OF CHRONIC EXPOSITION TO CHEMICAL FACTORS

Full Text

Abstract

Keywords

About the authors

O. V. Dolgikh

N. V. Zaitseva

A. V. Krivtsov

D. G. Dianova

E. A. Otavina

N. V. Bezruchenko

M. A. Guselnikov

References

Supplementary files

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