DETERMINATION OF THE LEVEL OF CD64 ON NEUTROFILES IN PATIENTS WITH SURGICAL SEPSIS



Cite item

Full Text

Abstract

The level of the expression of CD64 on neutrophils by fl ow cytometry in 49 patients with sepsis was studied, the dependence of these parameters on the degree of severity of the condition on the scale APACHEII (in points), the severity of multiple organ dysfunction scale SOFA (in points).High-level of expression on neutrophils nCD64 directly correlated with more severe organ dysfunction (SOFA), the weight of the state (APACHEII). These results may give the suggestion that presence of CD64 on neutrophils may serve as a biomarker refl ecting on the degree of systemic infl ammation in sepsis and may be a criterion in the prediction of the severity of disease and outcome in patients with sepsis.

About the authors

V. A. Lazanovich

Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation

Author for correspondence.
Email: immuno2003@mail.ru

Ph.D., assistant professor, Department of normal and Pathological Physiology,

Vladivostok

Russian Federation

A. V. Кostyushko

Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation

Email: fake@neicon.ru

Ph.D., assistant professor, Department of normal and Pathological Physiology, 

Vladivostok

Russian Federation

V. B. Shumatov

Federal State Budget Educational Institute of higher professional education Pacific State Medical University of Ministry of health Russian Federation

Email: fake@neicon.ru

Doctor of Sciences, Professor of the Department of intensive care, anesthesiology, intensive care and emergency medical services, 

Vladivostok

Russian Federation

References

  1. Hsu K. H., Chan M. C., Wang J. M. et al. Comparison of Fcγ receptor expression on neutrophils with procalcitonin for the diagnosis of sepsis in critically ill patients. Respirology. 2011; 16(1), 152–60.
  2. Icardi M., Erickson Y., Kilborn S. et al. CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J. Clin. Microbiol. 2009; (47): 3914–3919.
  3. Singer M., Deutschman S., Seymour C. W., ShankarHari M., Annane D., Bauer M et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8), 801–810.
  4. Stevenson E. K., Rubenstein A. R., Radin G. T., Wiener R. S., Walkey A. J. Two decades of mortality trends among patients with severe sepsis: a comparative metaanalysis. Crit Care Med. 2014;42, 625–631.
  5. Venet F., Lepape A. Clinical review: flow cytometry perspectives in the ICU – from diagnosis of infection to monitoring of injury-induced immune dysfunctions. Crit. Care. 2011; 15(5), 231.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Lazanovich V.A., Кostyushko A.V., Shumatov V.B.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies