HUMORAL AND CELLULAR IMMUNITY IN HUMANS VACCINATED AND REVACCINATED AGAINST MENINGOCOCCAL INFECTION



Cite item

Full Text

Abstract

T-lymphocytes of vaccinated peopleare involved in the post-vaccination immune response to the polysaccharide vaccine against the A, C, Y and W serogroups of N. meningitidis even if the vaccine is not a glycoprotein conjugate, but the functional activity of T-lymphocytes producing IFNγ and IL-4 is diff erent in the primary and secondary response to the vaccine.If in revaccinated people the humoral immune response to the A-polysaccharide of N. meningitidis is poorly developed, there is the lack of activity of T-lymphocytes that produce IFNγ in their blood and the change in the balance between the activity of Th1 and Th2 is more similar to the dynamics of the primary vaccinated people, rather than successfully revaccinated.

About the authors

M. S. Blyakher

G. N. Gabrichevsky Research Institute of epidemiology and microbiology
Moscow

Email: fake@neicon.ru

DSci (Medicine), Professor, Head of the Laboratory for the Study of Cellular and Molecular Bases of Immunity,

Moscow

Russian Federation

I. M. Fedorova

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

PhD (Medicine), Leading Researcher, Department of Immunology,

Moscow

Russian Federation

S. I. Koteleva

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

PhD (Medicine), Leading Researcher, Department of Immunology,

Moscow

Russian Federation

Z. K. Ramazanova

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

PhD (Medicine), Senior Researcher, Department of Immunology,

Moscow

Russian Federation

S. Yu. Kombarova

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

D. Sci (Biology), Head of Laboratory of Coccoid Infections,

Moscow

Russian Federation

I. G. Martynenko

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Email: fake@neicon.ru

Researcher, Laboratory of Coccoid Infections,

Moscow

Russian Federation

E. A. Tulskaya

G. N. Gabrichevsky Research Institute of epidemiology and microbiology

Author for correspondence.
Email: etul@mail.ru

PhD (Biology), Senior Researcher, Department of Immunology,

Moscow

Russian Federation

References

  1. Drogari-Apiranthitou M., Fijen C. A., van de Beek D., Hensen E. F., Dankert J., Kuij per E. J. Development of antibodies against tetravalent meningococcal polysaccharides in revaccinated complement-deficient patients. // Clin. Exp. Immunol. 2000; 119 (2): 311–316.
  2. Keiser P. B., Broderick M. Meningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response. // Hum. Vaccin. Immunother.2012; 8 (5): 582–586.
  3. Milagres L. G., Costa P. R., Santos B. A., Silva G. P., Cruz A. C., Perejra-Manfro W. F., Ferreira B., Barreto D. M. CD4+ T-cell activation impairs serogroup C Neisseria meningitis vaccine response in HIV-infected children.// AIDS. 2013; 27 (17): 2697–2705.
  4. Elias J., Findlow J., Borrow R., Tremmel A., Frosch M., Vogel U. Persistence of antibodies in laboratory staff immunized with quadrivalent meningococcal polysaccharide vaccine. // J. Occup. Med.Toxicol. 2013; 4 (1): 4.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Blyakher M.S., Fedorova I.M., Koteleva S.I., Ramazanova Z.K., Kombarova S.Y., Martynenko I.G., Tulskaya E.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies