INFLAMMASOMES AND INFLAMMATION

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  • Authors: Garib F.Y.1,2,3, Rizopulu A.P.4
  • Affiliations:
    1. Russian Medical Academy of Сontinuing Professional Education
    2. M. V. Lomonosov Moscow State University
    3. I.M. Sechenov First Moscow State Medical University
    4. The State Duma of Russian Federation
  • Issue: Vol 20, No 4 (2017)
  • Pages: 30-36
  • Section: REVIEWS
  • URL: https://rusimmun.ru/jour/article/view/106
  • ID: 106

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Abstract

The formation of multimolecular complex: inflammasome is a platform for caspases’ activation, which process proinflammatory cytokines into biologically active forms (IL­1 and IL­18). Their secretion initiate and maintain the inflammation. Inflammasome activation is able to trigger the pyroptosis in the infected host cells in order to eliminate microbial pathogens.

About the authors

F. Yu. Garib

Russian Medical Academy of Сontinuing Professional Education; M. V. Lomonosov Moscow State University; I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: fgarib@yandex.ru

PhD, MD (Medicine), professor, the Department of Immunology; Biological Faculty, the Department of Immunology, Professor; Professor the Department of Clinical Immunology and Allergolody

125993, Moscow, Barrikadnay str., 2/1, 1

Russian Federation

A. P. Rizopulu

The State Duma of Russian Federation

Email: fake@neicon.ru

PhD, MD (Biology)

Moscow

Russian Federation

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